首页|重组人干扰素α2β栓治疗HPV感染的临床观察

重组人干扰素α2β栓治疗HPV感染的临床观察

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目的 分析重组人干扰素α2β栓治疗HPV感染的临床疗效.方法 选取2015年1月~2016年12月100例医院诊治的经实验室检查确诊为HPV感染的患者,按照数字表法随机分为观察组与对照组,每组50例.观察组采用重组人干扰素α2β栓治疗,对照组则采用聚甲酚磺醛阴道栓治疗.比较2组患者的临床疗效,并比较2组患者治疗前后病毒载量变化,同时记录2组患者治疗期间的不良反应发生率.结果观察组的治疗有效率显著高于对照组(P<0.05);2组患者治疗前后病毒载量比较差异均有统计学意义(P<0.05),观察组病毒载量降低量显著高于对照组(P<0.05);2组患者治疗期间均无明显不良反应.结论 重组人干扰素α2β栓在HPV感染中具有较好的临床疗效,能够有效提高病毒清除效率、降低病毒载量,并且具有较高的安全性.
Clinical observation of recombinant human interferon α2β suppository in the treatment of HPV infection
Objective To analyze the clinical efficacy of recombinant human interferon alpha 2 beta suppository in the treatment of HPV infection. Methods 100 cases of hospital diagnosis and treatment of laboratory diagnosis of HPV infection from January 2015 to December 2016 were randomly divided into observation group and control group according to the digital table method, each group 50 cases. The observation group was treated with recombinant human interferon alpha 2 beta suppository treatment, control group with treatment of Policresulen Vaginal Suppository. The clinical efficacy of the two groups was compared and the changes of viral load before and after treatment were compared between the two groups. Meanwhile, the incidence of adverse reactions in the two groups during the treatment period was recorded. Results The effective rate of the observation group was significantly higher than the control group (P<0.05); two groups of patients before and after treatment of viral load differences were statistically significant (P<0.05), the observation group decreased viral load was significantly higher than the control group (P<0.05); during the two groups of patients had no obvious adverse reaction. Conclusion Recombinant human interferon alpha 2 beta suppository has good clinical efficacy in HPV infection, the virus can effectively improve the removal efficiency and reduce viral load, and high safety, is worthy of clinical application.

recombinant human interferon α2β suppositoryHPV infectionclinical efficacy

伍志虹、魏静

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福建省厦门市第一医院思明分院 妇产科,福建 厦门 361004

福建省厦门市湖里区妇幼保健院,福建厦门 361006

重组人干扰素α2β栓 HPV感染 临床疗效

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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