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地屈孕酮联合黄体酮治疗复发性流产的临床观察

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目的 探讨地屈孕酮联合黄体酮治疗复发性流产的临床疗效及安全性.方法 选取2014年4月~2016年4月浙江省苍南县人民医院诊治的100例复发性流产的孕妇,根据治疗方法进行分组,对照组50例,肌注黄体酮,40 mg/d,怀孕70 d后剂量减半,直至孕12周.研究组在对照组治疗基础上服用地屈孕酮,第1次剂量为40 mg,之后剂量调整为10 mg,1次/8 h,观察出血症状得到控制且临床症状消失后停药.观察并比较2组患者足月生产率、早产成活率、流产率、分娩孕周数.观察并比较2组妊娠≥7周、妊娠8~12 w时,血清人体绒膜促性腺激素(HCG)及孕酮(P)水平.观察并比较2组治疗期间不良反应发生情况.结果 研究组足月生产率明显高于对照组,流产率明显低于对照组,分娩孕周数明显高于对照组,差异有统计学意义(P<0.01).研究组妊娠≤7周、妊娠8~12 w时,血清HCG及孕酮水平均明显高于对照组,经比较差异有统计学意义(P<0.01).2组不良反应发生率差异无统计学意义.结论 地屈孕酮联合黄体酮能够有效治疗复发性流产,临床疗效显著,安全可靠.
Clinical effect of diprogesterone combined with progesterone in treatment of recurrent abortion
Objective To explore the clinical effect of diprogesterone combined with progesterone in treatment of recurrent abortion. Methods 100 pregnant women with recurrent abortions were grouped according to treatment methods. In the control group, 50 patients were injected with progestin, 40 mg/d, and the dose was halved to 12 weeks after conception. Team in the control group therapy on the basis of taking progesterone to bend, 1 dose of 40 mg, dose after adjustment for 10 mg, 1/8 h, observe bleeding symptoms under control and clinical symptoms disappeared after drug withdrawal. To observe and compare the total monthly productivity, preterm birth rate, miscarriage rate and number of pregnancies in the two groups. The serum human chorionic gonadotropin (HCG) and progesterone (P) levels were observed and compared between the two groups. The adverse reactions were observed and compared between the two groups. Results The productivity of the study group was significantly higher than that in the control group. The abortion rate was significantly lower than that in the control group, and the number of pregnancies was significantly higher than the control group, and the difference was statistically significant (P<0.01). The results showed that the serum HCG and progesterone levels were significantly higher than those in the control group, and the difference was statistically significant (P<0.01). There was no statistically significant difference between the two groups. Conclusion The combined progesterone combined with progesterone can effectively treat recurrent miscarriage, and the clinical efficacy is significant and safe and reliable.

recurrent abortionprogesteronediprogesterone

尤李智、杜少霞

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浙江省苍南县人民医院 产科,浙江 温州 325800

浙江省苍南县人民医院 妇科,浙江 温州 325800

复发性流产 黄体酮 地屈孕酮

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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