还原型谷胱甘肽对老年肝硬化患者ALB、BA、PA、ChE水平的影响
Effects of reduced glutathione on ALB, BA, PA and ChE levels in elderly patients with liver cirrhosis
王利健 1陈俊 1傅晓娟1
作者信息
- 1. 浙江省义乌市中心医院 检验科,浙江 义乌 322000
- 折叠
摘要
目的 分析还原型谷胱甘肽对老年肝硬化患者ALB、BA、PA、ChE水平的影响,探讨其在肝硬化肝功能评价及治疗疗效中的价值.方法 选取2015年8月~2016年8月于浙江省义乌市中心医院就诊的老年肝硬化患者122例,给予还原型谷胱甘肽治疗,分别于治疗后1周、2周、3周后检测患者血清中ALB、BA、PA、ChE水平,同时评估肝硬化患者治疗效果.采用溴甲酚氯法检测ALB,酶循环法检测BA,免疫比浊法检测PA,速率法检测ChE.结果 治疗后1周有效者18例,无效者104例;第2周有效者40例,无效者82例;第3周有效者40例,无效者37例.治疗前及治疗后1、2、3周老年肝硬化患者ALB比较差异均无统计学意义.和治疗前相比,治疗后2、3周BA显著降低(P<0.05);和治疗后2周相比,治疗后3周BA显著降低(P<0.05).和治疗前及治疗后1周相比,治疗后2、3周PA显著上升(P<0.05).和治疗前及治疗后1周相比,治疗后3周ChE显著上升(P<0.05).治疗疗效与ALB无显著相关性(r=0.125,P=0.534);治疗疗效与BA呈显著负相关(r=-0.698,P=0.04);治疗疗效与PA、ChE均呈正相关(r=0.753,P=0.03;r=-0.621,P=0.04).结论 还原型谷胱甘肽治疗老年肝硬化效果显著,能够显著影响ALB、BA、PA、ChE等水平,ALB、BA、PA、ChE等水平有助于评估患者治疗疗效.
Abstract
Objective To evaluate the effect of reduced glutathione on the levels of ALB, BA, PA and ChE in elderly patients with liver cirrhosis, and to explore its value in the evaluation of liver function and the therapeutic effect of liver cirrhosis. Methods A total of 122 patients with senile cirrhosis who were treated in our hospital from August 2015 to August 2016 were treated with reduced glutathione, and serum ALB was detected at 1 week, 2 weeks and 3 weeks after treatment. BA, PA, ChE levels were evaluated at the same time in patients with liver cirrhosis. ALB was detected by bromomethyl chloride method, BA was detected by enzyme cycle method, PA was detected by immunoturbidimetry, and ChE was detected by rate method. Results 18 cases were effective 1 week after treatment, 104 cases were ineffective; 40 cases were effective in the second week, 82 cases were ineffective; 40 cases were effective in the third week, 37 cases were ineffective. There was no significant difference in ALB between the two groups before and after treatment. Compared with 2 weeks after treatment, BA was significantly decreased (P<0.05), at 3 weeks after treatment compared with that before treatment. PA was significantly increased (P<0.05) at 2 weeks after treatment compared with 1 week before treatment and 1 week after treatment. Compared with 1 week before treatment and 1 week after treatment, ChE increased significantly (R =0.125, P = 0.534). There was a significant negative correlation between the curative effect and BA (r =-0.698, P = 0.04). The therapeutic effect was positively correlated with PA and ChE (r = 0.753 , P = 0.03; r =-0.621, P = 0.04). Conclusion Reduced glutathione can significantly affect the levels of ALB, BA, PA and ChE in the treatment of senile cirrhosis, and the levels of ALB, BA, PA and ChE can help to evaluate the curative effect of patients.
关键词
还原型谷胱甘肽/肝硬化/老年/血清白蛋白/胆汁酸/前白蛋白/胆碱酯酶Key words
reduced glutathione/liver cirrhosis/elderly/serum albumin/bile acid/prealbumin/cholinesterase引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据