The clinical therapeutic effect of cycloserine in the treatment of MDR -resistant tuberculosis
Objective To compare the clinical efficacy of serine and ethambutol in the treatment of multidrug-resistant tuberculosis. Methods 95 cases of multi drug resistant pulmonary tuberculosis patients in our hospital from January 2016 to April 2017 were randomly divided into treatment group and control group, treatment group were treated with cycloserine and control group treated with ethambutol, then compared two groups of patients with treatment of sputum culture negative conversion rate, lesion cavity closure and adverse reaction. Results The culture conversion rate of treatment group was significantly higher than the control group in the 6,12,18 months after treatment of sputum (P<0.05), the total effective rate of treatment group was 69.3%, significantly higher total efficiency of 58.6% in the control group (P<0.05), in the liver and kidney function damage, bone marrow suppression and mental disorders and other adverse reactions, the treatment group the incidence rate was significantly lower than the control group (P<0.05). Conclusion In the treatment of multi drug resistant pulmonary tuberculosis, the use of serine can improve the therapeutic effect and reduce the incidence of adverse reactions, and has clinical value.
NETL
NSTL
万方数据
维普
