Clinical effect of prednisone combined with psychological intervention on primary nephrotic syndrome in children
Objective To study the clinical effect of prednisone combined with psychological intervention on children with primary nephrotic syndrome. Methods 120 cases of children with primary nephrotic syndrome enrolled in our hospital from August 2013 to August 2016 were randomly selected as the object of study, and were divided into control group and observation group, with 60 cases in each group. The control group was treated with prednisone, the observation group was treated with prednisone and supplemented by psychological intervention. The levels of 24 h urinary protein quantitation, serum albumin and serum cholesterol content, blood creatinine, blood urea nitrogen and serum creatinine clearance were measured before and after treatment. The adverse reactions and treatment compliance of children in two groups were recorded. Results There was no significant difference in the clinical efficacy between the two groups after treatment. In the two groups, the 24 h urinary protein quantitation,serum cholesterol content, serum creatinine and urea nitrogen were significantly lower than those before treatment, the serum albumin and serum creatinine clearance rate were significantly higher than those before treatment (P<0.05). There was no statistical difference in the indicators between the two groups after treatment. The adverse reaction rate was 3.33% (2/60) in the observation group, which was significantly lower than that in the control group (15.00%, 9/60)(χ2=4.90 , P=0.02). The compliance of the observation group was significantly higher than that of the control group (P<0.05). Conclusion Application of prednisone combined with psychological intervention and the application of prednisone in the treatment of children with primary nephrotic syndrome is equivalent, but supplemented by psychological intervention may improve its compliance and reduce the incidence of adverse reactions.
prednisoneprimary nephrotic syndromepediatricpsychological care
NETL
NSTL
万方数据
维普
