强的松联合心理干预对小儿原发性肾病综合征的临床影响
Clinical effect of prednisone combined with psychological intervention on primary nephrotic syndrome in children
赵玲玲 1章敏 1周成1
作者信息
- 1. 温州医科大学附属第二医院 育英儿童医院 儿童肾内科,浙江 温州 325000
- 折叠
摘要
目的 研究强的松联合心理干预对小儿原发性肾病综合征患者的临床影响.方法 随机选取温州医科大学附属第二医院2013年8月~2016年8月收治的120例小儿原发性肾病综合征患者作为研究对象,分为对照组与观察组,各60例.对照组采用强的松治疗;观察组采用强的松治疗同时辅以心理干预.评价2组临床疗效,并于治疗前、治疗后检测2组24 h尿蛋白定量、血清白蛋白及血清胆固醇含量、血肌酐、尿素氮、血肌酐清除率,记录2组不良反应及患儿治疗依从性.结果 2组治疗后临床疗效相比较,差异无统计学意义;2组治疗后24 h尿蛋白定量及血清胆固醇含量、血肌酐、尿素氮较治疗前显著下降,血清白蛋白、血肌酐清除率较治疗前明显升高(P<0.05);2组间治疗后各项指标相比较,差异无统计学意义.观察组不良反应率3.33%(2/60),明显低于对照组15.00%(9/60)(χ2=4.90,P=0.02);观察组患儿治疗依从性明显高于对照组(P<0.05).结论 应用强的松联合心理干预与单纯应用强的松治疗小儿原发性肾病综合征疗效相当,但辅以心理干预可有效提高其治疗依从性,减少不良反应的发生.
Abstract
Objective To study the clinical effect of prednisone combined with psychological intervention on children with primary nephrotic syndrome. Methods 120 cases of children with primary nephrotic syndrome enrolled in our hospital from August 2013 to August 2016 were randomly selected as the object of study, and were divided into control group and observation group, with 60 cases in each group. The control group was treated with prednisone, the observation group was treated with prednisone and supplemented by psychological intervention. The levels of 24 h urinary protein quantitation, serum albumin and serum cholesterol content, blood creatinine, blood urea nitrogen and serum creatinine clearance were measured before and after treatment. The adverse reactions and treatment compliance of children in two groups were recorded. Results There was no significant difference in the clinical efficacy between the two groups after treatment. In the two groups, the 24 h urinary protein quantitation,serum cholesterol content, serum creatinine and urea nitrogen were significantly lower than those before treatment, the serum albumin and serum creatinine clearance rate were significantly higher than those before treatment (P<0.05). There was no statistical difference in the indicators between the two groups after treatment. The adverse reaction rate was 3.33% (2/60) in the observation group, which was significantly lower than that in the control group (15.00%, 9/60)(χ2=4.90 , P=0.02). The compliance of the observation group was significantly higher than that of the control group (P<0.05). Conclusion Application of prednisone combined with psychological intervention and the application of prednisone in the treatment of children with primary nephrotic syndrome is equivalent, but supplemented by psychological intervention may improve its compliance and reduce the incidence of adverse reactions.
关键词
强的松/原发性肾病综合征/小儿/心理护理Key words
prednisone/primary nephrotic syndrome/pediatric/psychological care引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据