首页|缺血修饰白蛋白、CK-MB、肌钙蛋白I联合检测在急性冠脉综合征诊断中的应用

缺血修饰白蛋白、CK-MB、肌钙蛋白I联合检测在急性冠脉综合征诊断中的应用

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目的 研究缺血修饰白蛋白IMA、CKMB、肌钙蛋白I联合检测在急性冠脉综合征诊断中的应用.方法 选择2015年9月~2016年12月在天津市宁河区医院治疗的急性冠脉综合征患者34例作为观察组,另选同期健康志愿者34例作为对照组.观察2组ROC曲线下的CK-MB、cTnl、IMA面积、CK-MB、cTnl、IMA的阳性、阴性及特异性百分比及测定结果值.结果 检测后,IMA阳性率为23.52%、特异性为76.47%,CK-MB阳性率为17.64%、特异性为82.35%,cTnl阳性率为11.76%、特异性为88.23%,各项指标的阳性率及特异性差异显著(P<0.05);ROC曲线下IMA面积明显高于CK-MB面积且低于cTnl面积(P<0.05);检测后,观察组IMA、CK-MB、cTnl水平与对照组相比,差异有统计学意义(P<0.05).结论 IMA、CK-MB、cTnl指标的联合检测对早期准确判定急性冠脉综合征具有重要的价值,可减少漏诊,对改善临床疗效具有积极作用.
Application of ischemic modified albumin, CKMB and troponin I in the diagnosis of acute coronary syndrome
Objective To study the application of ischemic modified albumin, CK-MB and troponin I in the diagnosis of acute coronary syndrome. Methods 34 patients with acute coronary syndrome treated in Tianjin Ninghe district hospital from September 2015 to December 2016 and 34 healthy volunteers treated in this hospital were selected. Those patients were divided into the control group and the observation group. The control group was healthy volunteers. The observation group was patients with acute coronary syndrome. The positive, negative and specificity of CK-MB, cTnl, IMA area, CK-MB, cTnl and IMA under ROC curve and the results were measured. Results The positive rate of IMA was 23.52%, the specific rate was 76.47%, the positive rate of CK-MB was 17.64% and the specific rate was 82.35%. The positive rate of cTnl was 11.76%, the specific rate was 88.23%, the positive rate and specific rate of each index were significantly different (P<0.05). The area of IMA was significantly higher than that of CK-MB and below cTnl (P<0.05). After examination, compared with the control group, the levels of IMA, CK-MB and cTnl in the observation group were significantly different (P<0.05). Conclusion Combined detection of IMA, CK-MB and cTnl has important value in early accurate diagnosis of acute coronary syndrome, which can reduce missed diagnosis, and has a positive effect on improving the clinical efficacy.

ischemic modified albuminCK-MBtroponin Iacute coronary syndrome

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天津市宁河区医院 检验科,天津市 301500

缺血修饰白蛋白 CK-MB 肌钙蛋白I 急性冠脉综合征

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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