Effect of limited fluid management on pulmonar dynamic compliance in treating acute lung injury with anisodamine combined with mechanical ventilation
Objective To analyze the effect of limited fluid management on pulmonary dynamic compliance in treating acute lung injury with anisodamine combined with mechanical ventilation. Methods 90 cases of patients with acute lung injury from February 2016 to January 2017 were randomly divided into control group and research group, with 45 cases for each and were provide with anisodamine combined with mechanical ventilation as treatment. Control group was provide with conventional nursing, while research group was provided with limited fluid management, strict observation of various indicators, adjust the amount of transfusion at any time according to the change of the disease. Two groups were compared for pulmonary dynamic compliance in 6 h, 24 h, 48 h and 72 h after management, oxygenation index, blood gas analysis and outcome. Results In comparing pulmonary dynamic compliance in 6 h after management between two groups, the difference had no statistical significance Pulmonary dynamic compliance in 24 h, 48 h and 72 h after management of research group were significantly higher than control group, with difference statistical significance (t=3.519, t=5.622, t=7.090, P<0.05). The improvement of oxygenation index, PaO2 and PaCO2 w in research group were significantly higher than control group, with difference having statistical significance (t=5.511, t=9.523, t=3.040, P<0.05). In comparison of pH value after management between two groups, the difference had no statistical significance. In comparison of ICU rate and public ward rate between two groups, the difference had no statistical significance. The mortality of control group was 24.44%, which was obviously higher than that in research group with 13.33%, and the difference had statistical significance (χ2=4.029, P<0.05). Conclusion In treating patients with acute lung injury via anisodamine combined with mechanical ventilation, limited fluid management can effectively improve pulmonary dynamic compliance of patients and reduce mortality. In clinic, it can be applied in accordance with ALI specific condition.
NETL
NSTL
万方数据
维普
