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新生儿败血症临床特征和菌谱耐药分析

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目的 探讨新生儿败血症临床特征及菌谱耐药特点.方法 选择余姚市人民医院2010年1月~2015年12月收治的新生儿败血症200例,均行血培养,统计病原菌构成比,观察早发型、晚发型病原菌分布情况,并分析菌谱耐药率.结果 共分离出病原菌200株,革兰阴性菌28株,占14.00%,以肺炎克雷伯杆菌、大肠埃希菌最为常见;革兰阳性菌172株,占86.00%,以金黄色葡萄球菌、表皮葡萄球菌最为多见.113株为早发型败血症病原菌,占56.5%;87株为晚发型败血症病原菌,占43.5%.结论 通过分析新生儿败血症菌谱耐药特点,针对性对治疗用药进行选择,可最大程度改善预后.
Analysis of clinical features and bacterial spectrum drug-resistance in neonatal sepsis
Objective To investigate the clinical features, bacterial spectrum drug-resistance of neonatal sepsis. Methods 200 cases of neonatal septicemia in Yuyao People's hospital of Zhejiang Province from January 2010 to December 2015 were treated by blood culture, counting the constituent ratio of pathogens, the early and late-onset pathogen bacteria distribution observation and drug-resistance rate of bacteria spectrum analysis. Results A total of 200 strains of bacteria were isolated, 28 strains of gram negative bacteria accounted for 14.00%, with pulmonary Bauman Acinetobacter, Escherichia coli were the most common sterilization; 172 strains of gram positive bacteria accounted for 86.00%, Staphylococcus aureus, Staphylococcus epidermidis were the most common. 113 strains were early-onset septicemia pathogens, accounting for 56.5%; 87 were late-onset septicemia pathogens, accounting for 43.5%. Conclusion Through the analysis of the characteristics of bacterial spectrum drug-resistance of neonatal sepsis, targeted treatment options, could maximize the prognosis.

neonatal septicemiabacterial spectrum analysisdrug-resistance rate

张惠、叶青

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余姚市人民医院 儿科,浙江 余姚 315400

新生儿败血症 菌谱分析 耐药率

2017

中国生化药物杂志
南京生物化学制药研究所,全国生化制药情报中心站,中国生化制药工业协会,中国药品生物制品检定所

中国生化药物杂志

ISSN:1005-1678
年,卷(期):2017.37(11)
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