Clinical effect of erythromycin sequential therapy and changes of serum cytokines in children with mycoplasma pneumonia
Objective To investigate the clinical efficacy of erythromycin sequential therapy in children with mycoplasma pneumonia and the changes of serum cytokines in children. Methods 104 patients with mycoplasma pneumonia were enrolled in Tongde Hospital of Zhejiang Province from January 2015 to March 2017. They were divided into two groups. The control group was treated with conventional erythromycin therapy. The erythromycin sequential method was used in the treatment group. Clinical treatment efficacy, the disappearance time of symptoms, the incidence of adverse reactions and changes in cytokines of two groups of patients after treatment were compared. Results The total effective rate was 98.1% in the treatment group and 84.3% in the control group. The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The symptoms disappeared time, the time of disappearance of cough and the disappearance of lung features in the treatment group were significantly shorter than those of the control group (P<0.05). The incidence of adverse events in the treatment group was significantly lower than that in the control group (P<0.05). There was no significant difference in the levels of Hs-CRP, TNF-α and IL-8 in the two groups before treatment, after treatment, the levels of Hs-CRP, TNF-α and IL-8 in the treatment group were significant lower than those in the control group (P<0.05). Conclusion The application of erythromycin sequential therapy in the treatment of children with mycoplasma pneumonia has good clinical effect, could reduce the incidence of adverse reactions.
children with mycoplasma pneumoniaerythromycin sequential therapyclinical effectcytokines
NETL
NSTL
万方数据
维普
