重度哮喘应用舒利迭联合孟鲁司特治疗的效果分析
Analysis of the treatment effect of seretide combined with montelukast in severe asthma
彭秋凤 1高静珍1
作者信息
- 1. 天津市第四中心医院 呼吸内科,天津 300140
- 折叠
摘要
目的 探讨舒利迭联合孟鲁司特治疗重度哮喘的临床效果.方法 选取天津市第四中心医院2015年7月~2017年6月收治的100例重度哮喘为研究对象,随机分为2组各50例.对照组给予舒利迭治疗(50 mg/250μg),1天2次.实验组给予舒利迭联合孟鲁司特联合治疗.比较分析实验组与对照组患者的临床治疗效果、FEV1及不良反应等临床指标.结果 治疗前,实验组与对照组患者FEV1指标分别为(1.03±0.18)%与(1.04±0.24)%,差异无统计学意义.治疗后,实验组FEV1指标为(1.57±0.54)%显著高于对照组的(1.20±0.25)%(P<0.05).经过对应的治疗后,实验组患者的治疗有效率(94.0%)显著高于对照组的72.0%,差异具有统计学意义(P<0.05).实验组与对照组均未出现严重不良反应,不良反应发生率分别为6.0%及4.0%,差异无统计学意义.结论 重度哮喘应用舒利迭联合孟鲁司特治疗效果较为理想,可显著缓解患者临床症状,改善肺功能.
Abstract
Objective To investigate the clinical efficacy of seretide combined with montelukast in the treatment of severe asthma. Methods 100 cases of severe asthma from July 2015 to June 2017 were selected and randomly divided into two groups, with 50 cases in each group. The control group was treated with Seretide (50 mg/250 μg), two times a day. The experimental group was treated with seretide combined with montelukast. The clinical efficacy, FEV1 and adverse reactions were compared and analyzed between experimental group and control group. Results Before treatment, the FEV1 indexes of the experimental group and the control group were (1.03±0.18)%, and (1.04±0.24)%, and there was no statistical difference. After treatment, the FEV1 index in the experimental group was (1.57±0.54)% , which was significantly higher than that in the control group (1.20±0.25)%(P<0.05). After the corresponding treatment, the effective rate of treatment in the experimental group (94.0%) was significantly higher than that in the control group (72.0%), the difference was statistically significant (P<0.05). There were no serious adverse reactions in the experimental group and the control group, and the incidence of adverse reactions was 6.0% and 4.0% respectively, and there was no statistical significance. Conclusion Severe asthma using Seretide plus montelukast treatment effect is more ideal, can significantly relieve clinical symptoms, improve lung function.
关键词
重度哮喘/舒利迭/孟鲁司特Key words
severe asthma/seretide/montelukast引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据