地中海贫血的产前生化筛查检验方法和结果研究
Prenatal biochemical screening methods and results of thalassemia
邹前芽1
作者信息
- 1. 江西省吉安市中心人民医院 检验科,江西 吉安 343000
- 折叠
摘要
目的 对于地中海贫血的产前生化筛查检验方法和结果进行观察及分析.方法 选取2014年5月~2017年5月江西省吉安市中心人民医院实施产前筛查并分娩的2000例孕妇,对于孕妇的相关临床资料进行搜集并回顾性的分析.结果 通过予以孕妇产前生化筛查检验方式,在全部的孕妇中共检出了地中海贫血孕妇为23例,得到了1.15%的发病率.而且在这些病例中,β-HCG水平在2.5 mmol/L以上,AFP浓度在0.3 mmol/L以下,PAPP-A的水平在0.5 mmol/L以下.而且α-地中海贫血症病例和β-地中海贫血病症的病例数分别是5例、18例.同正常的孕妇相对比,α-地中海贫血症病例和β-地中海贫血病症的病例MCH以及MCV值相对更低,RDM值明显更高(P<0.05).结论 通过实施产前生化筛查检验举措,能够对于地中海贫血孕妇病例及时的发现,并能够有效的提升优生比率.
Abstract
Objective To observe and analyze the methods and results of prenatal biochemical screening for thalassemia. Methods 2000 pregnant women who underwent prenatal screening and delivery in our hospital were selected from May 2014 to May 2017. The clinical data of pregnant women were collected and analyzed retrospectively. Results By means of prenatal biochemical screening test, 23 cases of thalassemia were detected in all pregnant women, and the incidence rate was 1.15%. Moreover, in these cases, the level of beta -HCG was above 2.5mmol/L, the concentration of AFP was below 0.3mmol/L, and the level of PAPP-A was below 0.5mmol/L. Moreover, the number of cases of alpha thalassemia and beta thalassemia was 5 and 18 respectively. Compared with normal pregnant women, cases of alpha thalassemia and beta thalassemia were lower, MCH and MCV were lower, and RDM was significantly higher(P<0.05). Conclusion Through the implementation of prenatal biochemical screening test measures, can be timely detection of cases of thalassemia pregnant women, and can effectively improve the eugenic ratio.
关键词
地中海贫血/产前生化筛查/检验方法Key words
mediterranean anemia/prenatal biochemical screening/test methods引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据