Effect and safety of Phentolamine combined with Dopamine on treatment of severe pneumonia in children
Objective To study the effect of Phentolamine combined with Dopamine on the efficacy and safety of children with severe pneumonia. Methods 94 cases of severe pneumonia treated by the third People's hospital of Yinchuan city from May 2014 to July 2016 were selected as study objects, and 47 cases were divided into the observation group according to the random number table method, and 47 cases in the control group. The control group was treated with routine treatment, and the observation group was treated with Phentolamine combined with Dopaminergic therapy on the basis treatment of the control group. Curative effect, the clinical symptoms disappear time, the APACHE Ⅱ ratings before and after treatment and adverse reactions of two groups were compared. Results The total effective rate of the observation group was 93.62%(44/47), compared with 76.60% (36/47) in the control group, with significant difference (P<0.05). Various clinical symptoms disappear time, cough disappeared time in the observation group was (5.1±1.5) d, fever disappeared time was (3.1±1.2) d, then the sound disappear time wass (5.4±1.3) d, shortness of breath disappear time was (2.3±1.1) d, these were respectively lower than in the control group (9.4±3.1) d, (6.6±1.7) d, (9.2±1.6) d, (4.9±1.4) d, with significant difference (P<0.05). APACHE Ⅱ scores in the two groups after treatment were significantly decreased, while the observation group was significantly lower than the control group, the differences were statistically significant (P<0.05). The adverse reaction rate of the observation group was 8.51% (4/47), compared with 27.66% (13/47) of the control group, with significant difference (P<0.05). Conclusion The effect of Phentolamine combined with Dopamine in treating children with severe pneumonia is significant, which is beneficial to improve the clinical symptoms of children and can reduce the inflammatory response of the cells, and has good safety.
NETL
NSTL
万方数据
维普
