Expression of serum AFP, AFU, CEA and CA125 in patients with different liver diseases and their diagnostic value in primary liver cancer
Objective To study the expression level clinical significance ofserum AFP (AFP), alpha L- fucus glycosidase (AFU), carcinoembryonic antigen (CEA) and cancer antigen (CA125) in different liver disease and to analyze the diagnostic value to primary liver cancer. Methods From June 2014 to May 2017 in our hospital confirmed by clinical laboratory examination, 120 cases with hepatitis (hepatitis group), 76 cases with cirrhosis (cirrhosis group), 80 cases with primary hepatocellular carcinoma (HCC group) and 72 healthy subjects (control group) at the same period were selected as the research object. Individual serum AFP, AFU, CEA, CA125 and joint detection were performed on 4 groups of subjects, and the results were analyzed. Results Compared with the control group, AFP, AFU, CEA and CA125 were all increased in the hepatitis group, the cirrhosis group and the HCC group AFP (P<0.05). AFP in the HCC group was higher than that in the hepatitis group and was lower than that in the cirrhosis group(P<0.05). The levels of AFU, CEA and CA125 in HCC group were higher than those in hepatitis and cirrhosis group(P<0.05). A single index examination showed that the sensitivity of the AFP was 65.0%. The highest degree of specificity AFU was 69.40%. The positive predictive value was the highest in AFU, 83.33%. The negative predictive value was the highest in AFP, 86.0%; The combined test results showed that the sensitivity and specificity were higher than those in the single test, with a sensitivity of 82.5% and a specificity of 73.13%. Both positive and negative predictors were also higher than those in single tests. Conclusion AFP, AFU, CEA and CA125 in liver disease has important clinical significance, the joint detection can distinguish between the diagnosis of liver cancer and other liver diseases, can improve the sensitivity and accuracy of the diagnosis of liver cancer.
NETL
NSTL
万方数据
维普
