Progress and study on anti - tumor ability of peptide and PEG comodified liposomes
Liposomes are a major concern in the treatment of tumor drug delivery systems,such as the delivery of antimicrobial peptides, proteins, drugs and so on. PEG-modified liposomes can prolong the circulating time of liposomes in vivo, but it also has some drawbacks,for example,the weaker ability of PEG-modified liposomes to reach the tumor site will limit the ability of liposomes to enter the cells; Hinder pH-sensitive liposome cells within the "escape "; Repeated injection of PEG ylated liposomes in the same animal can induce accelerated blood clearance. In order to solve these problems, it has been studied to use peptides to modify liposomes in order to enhance targeting of tumor cells, peptides and PEG co-modified liposomes, and to make use of drug delivery systems promising. By summarizing the progress and innovation of the existing concept of liposomal drug delivery, we will focus on the advantages and disadvantages of polypeptide-mediated liposome targeting, and introduce the functions of emerging peptides and PEG co-modified liposomes .
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