Research progress of transcranial alternating current stimulation in the treatment of cognitive impairment in neuropsychiatric diseases
张雪琳 1杨秋丽 2司夏樱 1黄佩姗 1王克 1苗懿 1董强利1
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作者信息
1. 兰州大学第二医院心理卫生科(兰州 730000)
2. 宁夏回族自治区宁安医院
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摘要
认知功能障碍是脑高级功能的损伤,由神经精神疾病引起的认知功能损害对患者的生活质量和疾病转归造成严重影响.经颅交流电刺激(transcranial alternating current stimulation,tACS)通过调节特定频率的神经振荡、影响5-羟色胺和多巴胺等神经递质的释放、增强脑网络局部与远端的同步,达到改善认知功能的效果.特定频率的tACS可以改善阿尔茨海默病(Alzheimer disease,AD)、精神分裂症、抑郁障碍引起的认知功能损害,其中以gamma和theta频率tACS对认知功能的影响最为显著.tACS安全性高,操作难度小,对改善神经精神疾病患者的认知功能具有巨大潜力.
Abstract
Cognitive dysfunction is the impairment of higher brain functions.Cognitive impairment caused by neuropsychiatric diseases has caused serious impact on patients'quality of life and the outcome of the disease.The transcranial alternating current stimulation(tACS)improves cognitive function by modulating neural oscillations of specific frequencies,affecting the release of neurotransmitters such as serotonin and dopamine,and enhancing local and distal synchronization of brain networks.Specific frequencies of tACS can improve the cognitive impairment caused by Alzheimer disease(AD),schizophrenia,and depression,among which the gamma and theta frequencies of tACS have the most significant effects on cognitive function.tACS has high safety and low operational difficulty,and has great potential to improve cognitive function.
关键词
经颅交流电刺激/神经振荡/作用机制/认知功能/阿尔茨海默病/神经精神疾病/研究进展
Key words
Transcranial alternating current stimulation/Neural oscillation/Mechanism of action/Cognitive func-tion/Alzheimer disease/Neuropsychiatric disease/Research progress
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