双相障碍认知功能损害与外周炎症关系研究进展
The role of peripheral inflammation in cognitive impairments of bipolar disorder
程晓菲 1李名立2
作者信息
- 1. 四川大学华西医院心理卫生中心(成都 610041)
- 2. 四川大学华西医院心理卫生中心(成都 610041);四川省临床医学研究中心
- 折叠
摘要
认知功能损害是双相障碍患者的核心症状之一,但其病理生理机制尚不明确,且治疗难度大.近年研究发现外周炎症与双相障碍的认知功能损害有关,即持续较高的外周炎症水平可能通过神经递质改变、下丘脑-垂体-肾上腺轴过度激活以及微生物-肠-脑轴异常等途径导致双相障碍患者的认知功能损害.阐明该关系可为双相障碍认知功能损害的临床诊疗提供新的思路.
Abstract
As one of the core symptoms of bipolar disorder,cognitive impairment is difficult to treat,and the mechanism of it remains unclear.Recent studies have indicated the association between peripheral inflammation and cognitive impairments in bipolar disorder.That is,consistent high level of peripheral inflammation may lead to cognitive impairment in patients with bipolar disorder through neurotransmitter alterations,hyperactivation of the hypothalamic-pituitary-adrenal axis and abnormality of microbial-gut-brain axis.Clarifying the association could provide new ideas for clinical diagnosis and treatment of cognitive impairments in bipolar disorder.
关键词
双相障碍/炎症/认知功能/生物学机制/神经递质/下丘脑-垂体-肾上腺轴/微生物-肠-脑轴Key words
Bipolar disorder/Inflammation/Cognition/Biological mechanism/Neurotransmitter/Hypothalamic-pituitary-adrenal axis/Microbiome-gut-brain axis引用本文复制引用
基金项目
国家自然科学基金(82071524)
科技创新——"脑科学与类脑研究"重大项目(2030)(2021ZD0202100)
出版年
2024
NETL
NSTL
维普
万方数据