纳米材料在鼻脑通路治疗胶质母细胞瘤研究进展
Research progress of nanomaterials in nose-to-brain delivery for glioblastoma treatment
宋子彬 1袁嘉杰 1陈云娇 1李健沨 1潘军1
作者信息
- 1. 南方医科大学南方医院神经外科,脑病研究院(广州 510515)
- 折叠
摘要
胶质母细胞瘤(glioblastoma,GBM)是最致命的肿瘤之一,由于血脑屏障(blood-brain barrier,BBB)的存在,其药物治疗受到了严重限制.鼻脑通路递药作为一种通过鼻内途径输送药物至中枢神经系统(central ner-vous system,CNS)的给药方式,可以避开BBB直接靶向脑部.鼻腔分为前庭区、嗅觉区和呼吸区.纳米药物可以通过嗅觉区的嗅神经通路和呼吸区的三叉神经通路实现高效运输到CNS.近年来,纳米递药平台在经鼻给药治疗GBM的研究中得到广泛关注,主要涉及聚合物、脂质体、无机金属纳米颗粒等方式.这些技术的发展为克服BBB、提高药物传递效率以及改善GBM患者预后提供了新的思路和选择.
Abstract
Glioblastoma(GBM)stands as one of the most aggressive brain tumors,and its pharmacological therapy is severely limited due to the presence of the blood-brain barrier(BBB).Nose-to-brain drug delivery has emerged as a promising approach for directly targeting the central nervous system(CNS)by circumventing the BBB.The nasal cavity is anatomically partitioned into the vestibular,olfactory,and respiratory regions.Nanomedicines can efficiently transport to the CNS through the olfactory pathway of the olfactory region and the trigeminal nerve pathway of the respiratory region.In recent years,nanodelivery platforms in nasal administration for treating GBM have garnered widespread attention,primarily involving polymers,liposomes,inorganic metal nanoparticles,and so on.The advancement of these technologies presents novel avenues and selections for overcoming the BBB,enhancing drug delivery efficacy,and improving the prognosis of GBM patients.
关键词
胶质母细胞瘤/鼻脑通路/聚合物/脂质体/无机金属纳米材料Key words
Glioblastoma/Nose-to-brain pathway/Polymers/Liposomes/Inorganic metal nanomaterials引用本文复制引用
基金项目
国家自然科学基金面上项目(81972352)
出版年
2024
NETL
NSTL
万方数据