基于体素形态学分析探讨脑梗死远隔丘脑和黑质损害研究
Investigating the distant thalamic and substantia nigra damage in patients with cerebral infarction based on voxel morphology analysis
陈丹霞 1徐炳东 2皮凤玲 3张玉生2
作者信息
- 1. 梅州市人民医院神经内科;暨南大学附属第一医院神经内科(广州 510630)
- 2. 暨南大学附属第一医院神经内科(广州 510630)
- 3. 暨南大学附属第一医院医学影像科
- 折叠
摘要
目的 探讨颅脑核磁共振成像(magnetic resonance imaging,MRI)体素形态学分析(voxel-based mor-phometry,VBM)对检测脑梗死患者远隔丘脑和黑质继发性损害的临床价值.方法 前瞻性招募19例首次单侧大脑中动脉(middle cerebral artery,MCA)供血区脑梗死患者,在发病后1周、1个月、3个月分别行MRI三维全脑扫描,应用VBM方法分析丘脑和黑质体积的变化.结果 VBM结果显示,与发病1周时相比,脑梗死患者在发病1个月和3个月时同侧丘脑体积减小(体素值分别缩小637 mm3、1488 mm3,P<0.01),且体积萎缩部位主要位于丘脑背内侧核.同样,与发病1周时相比,脑梗死患者在发病1个月和3个月时同侧黑质体积减小(体素值分别缩小64 mm3、76 mm3,P<0.05).结论 VBM技术可在脑梗死后1～3个月检测MCA供血区脑梗死患者同侧丘脑和黑质体积缩小,可用于检测其继发性损害.
Abstract
Objective To explore the clinical values of voxel-based morphometry(VBM)analysis in magnetic resonance imaging(MRI)for detecting secondary damage to the distant thalamus and substantia nigra in patients with cerebral infarction.Methods A total of nineteen patients with first-time unilateral middle cerebral artery(MCA)ischemic stroke were prospectively recruited.Three-dimensional whole-brain MRI scans were performed at 1 week,1 month,and 3 months after onset.VBM analysis was used to analyze changes in the thalamus and substantia nigra volumes.Results VBM analysis revealed that compared to ipsilateral thalamic volume at 1 week after onset,ipsilateral thalamic volume was significantly reduced at 1 month or 3 months after onset(reduced by 637 mm3 and 1488 mm3,respectively;P<0.01),with the atrophy primarily located in the dorsomedial nucleus of the thalamus.Similarly,compared to ipsilateral substantia nigra volume at 1 week after onset,the ipsilateral substantia nigra volume was significantly reduced at 1 month or 3 months after onset(reduced by 64 mm3 and 76 mm3,respectively;P<0.05).Conclusions VBM technology can be used to evaluate the ipsilateral thalamic and substantia nigra volume reduction in patients with cerebral infarction in the MCA supply area at 1-3 months after stroke,and to detect secondary damage.
关键词
体素形态学分析/大脑中动脉/脑梗死/丘脑/黑质/远隔损害/磁共振成像Key words
Voxel-based morphometry/Middle cerebral artery/Cerebral infarction/Thalamus/Substantia nigra/Secondary damage/Magnetic resonance imaging引用本文复制引用
基金项目
广东省自然科学基金面上项目(2020A1515011249)
中央高校基本科研业务费专项(21620406)
广州市科技计划(2023A03J0577)
梅州市科技计划(2023B36)
出版年
2024
NETL
NSTL
万方数据