脑小血管病影像学标志物与认知功能障碍相关性研究进展
Research progress on the correlation between imaging markers and cognitive dysfunction in cerebral small vessel disease
邢楠 1华素玉 2李俐涛2
作者信息
- 1. 华北理工大学研究生院(唐山 063210);河北省人民医院神经内六科
- 2. 河北省人民医院神经内六科
- 折叠
摘要
脑小血管疾病(cerebral small vessel disease,CSVD)的部分患者会出现认知功能下降并可能进展为痴呆,严重降低患者的生活质量.目前关于CSVD影像学标志物与认知功能障碍的相关性研究表明,脑白质高信号、血管周围间隙扩大、脑微出血、腔隙性脑梗死的分布位置、严重程度对各认知域产生不同影响,CSVD导致的认知功能障碍可能与炎症因子间接影响和脑组织纤维束破坏等机制相关.但CSVD影像学标志物与认知功能的关系及其相关机制还需要更进一步研究加以验证.
Abstract
Some patients with cerebral small vessel disease(CSVD)may experience cognitive decline and may progress to dementia,which seriously impairs the quality of life of patients.Current studies on the correlation between CSVD imaging markers and cognitive impairment have shown that the distribution and severity of white matter hyperintensity(WMH),enlarged perivascular spaces(EPVS),cerebral microbleeds(CMB),and lacunar infarction(LI)have different effects on various cognitive domains.The cognitive dysfunction caused by CSVD may be related to indirect effects of inflammatory factors and damage to the brain tissue fiber bundles.However,the relationship between CSVD imaging markers and cognitive function and its related mechanisms still need to be further studied and verified.
关键词
脑小血管病/影像学标志物/脑白质高信号/血管周围间隙扩大/脑微出血/腔隙性梗死/认知功能Key words
Cerebral small vessel disease/Imaging markers/White matter hyperintensity/Enlarged perivascular space/Cerebral microbleedings/Lacunar infarction/Cognitive function引用本文复制引用
基金项目
河北省自然科学基金(H2022307073)
出版年
2024
NETL
NSTL
万方数据