遗忘型轻度认知功能障碍患者脑灌注和听觉认知能力相关性
The correlation between cerebral perfusion and auditory cognitive ability in patients with amnestic mild cognitive impairment
李海涛 1沈佳媛 2鄢慧琴 3李小帅 4刘玉和5
作者信息
- 1. 首都医科大学附属北京友谊医院神经内科(北京 100050)
- 2. 首都医科大学附属北京友谊医院耳鼻咽喉头颈外科;浙江省中医院耳鼻喉科
- 3. 广州医科大学耳鼻咽喉头颈外科研究所附属惠州医院
- 4. 首都医科大学附属北京友谊医院影像科
- 5. 首都医科大学附属北京友谊医院耳鼻咽喉头颈外科
- 折叠
摘要
目的 探究遗忘型轻度认知功能障碍(amnestic mild cognitive impairment,aMCI)患者的脑灌注与听觉认知能力的相关性.方法 以 2022年7月至2023年9月北京友谊医院记忆门诊就诊的aMCI患者作为研究对象,并纳入性别和年龄与患者匹配的健康对照者进行对比研究.所有受试者使用3.0 T MRI进行动脉自旋标记(arte-rial spin labeling,ASL)扫描,并且采用汉语"重复-回忆"言语认知功能测试(repeat-recall test,RRT)评估听觉认知能力,分析脑血流量(cerebral blood flow,CBF)改变和听觉认知能力的相关性.结果 共纳入26例aMCI患者(aMCI组)和32名健康对照者(对照组).不论高低语境和信噪比(signal to noise ratio,SNR)大小,aMCI组的听觉认知能力较对照组均下降,差异有统计学意义(P<0.01).aMCI组左侧顶下小叶标准化CBF值较对照组明显减低(0.921±0.234 vs.1.247±0.076),差异存在统计学意义(P<0.001).相关性分析发现,aMCI组左侧顶下小叶标准化CBF值与在低语境条件-5 dB信噪比下的听觉认知能力相关(r=0.857,P<0.001).结论 aMCI患者左侧顶下小叶的CBF下降可能与听觉认知损害具有一定的相关性.
Abstract
Objective To explore the correlation between changes in cerebral blood flow and auditory cognitive function in patients with amnestic mild cognitive impairment(aMCI).Methods The aMCI patients who visited the Memory Clinic of Beijing Friendship Hospital from July 2022 to September 2023 were selected as the research subjects,and gender and age matched healthy controls were included in the comparative study.All subjects underwent ASL scans using 3.0 T MRI and underwent a Chinese"repeat-recall"verbal cognitive function test(RRT)as an assessment of auditory cognitive abilities,and the correlation between cerebral blood flow(CBF)changes and auditory cognitive function was finally analyzed.Results A total of 26 patients with aMCI and 32 normal healthy were included.Regardless of the high and low context and signal to noise ratio(SNR),the auditory cognitive ability of the aMCI group significantly decreased compared to the control group(P<0.01).The standardized CBF value of the left inferior parietal lobule in the aMCI group was significantly reduced compared to the control group(0.921±0.234 vs 1.247±0.076,P<0.001).Correlation analysis showed that the standardized CBF value of the left inferior parietal lobule in the aMCI group was correlated with auditory cognitive ability under low contextual conditions of-5 dB signal-to-noise ratio(r=0.857,P<0.001).Conclusion CBF in the left inferior parietal lobe in patients with aMCI may have some relevance for auditory cognitive impairment.
关键词
认知功能障碍/遗忘型/脑血流量/听觉中枢功能障碍/听觉认知能力评估/磁共振脑灌注成像/动脉自旋标记/重复-回忆检查Key words
Cognitive impairment/Amnestic/Cerebral blood flow/Auditory central dysfunction/Assessment of auditory cognitive ability/Magnetic resonance cerebral perfusion imaging/Arterial spin labeling/Repeat recall test引用本文复制引用
基金项目
北京市医疗管理中心十大专业建设项目(Q19051-07)
北京友谊医院科研启动基金(yyqdkt2020-3)
出版年
2024
NETL
NSTL
万方数据