低级别胶质瘤临床治疗进展
Progress in clinical treatment of low-grade gliomas
郭鹏航 1谢东 1赵全堂 1高宇 1南亚强 1曾广红 1周杰1
作者信息
- 1. 中国人民解放军联勤保障部队第九四〇医院神经外科 甘肃中医药大学第一临床学院(兰州730000)
- 折叠
摘要
低级别胶质瘤(low-grade glioma,LGG)是起源于胶质细胞的原发性脑肿瘤,生长缓慢,总体预后较好,但不能治愈,绝大多数仍会复发,甚至进展为高级别胶质瘤(high-grade glioma,HGG).LGG治疗方案至今仍存在争议,目前治疗包括手术切除,放疗(radiation therapy,RT)、化疗(chemical treatment),靶向及免疫治疗,但其有效性和安全性有待进一步临床探索.现对LGG的治疗方案包括手术、放疗、化疗、靶向及免疫治疗等方面进行阐述,以便制定个体化的治疗方案,为最大化地延长患者生存时间,改善患者预后提供理论策略.
Abstract
low-grade glioma(LGG)is a slow-growing primary brain tumor originating from glial cells.The overall prognosis of LGG is good but incurable.The vast majority of LGG will have relapses,and some even progress to high-grade glioma(HGG).The treatment of LGG is still controversial.The current treatment includes surgical resection,radiation therapy(RT),chemical treatment(CT),targeting and immunotherapy,but its effectiveness and safety need further clinical exploration.This article describes the treatment of LGG,including surgery,radiotherapy,chemotherapy,targeting and immunotherapy,in order to develop an individualized treatment plan and provide theoretical strategies for maximizing the survival time of patients and improving the prognosis of patients.
关键词
低级别胶质瘤/手术/放疗/化疗/靶向治疗/免疫治疗Key words
Low-grade gliomas(LGG)/Surgery/Radiotherapy/Chemotherapy/Targeted therapy/Immune therapy引用本文复制引用
基金项目
甘肃省自然科学基金(23JRRA532)
兰州市科技基金(2023-ZD-167)
中国人民解放军联勤保障部队第九四〇医院院内基金(2022yxky011)
出版年
2024
NETL
NSTL
万方数据