功能磁共振成像评估抑郁症心理治疗后脑功能变化研究进展
Advances in functional magnetic resonance imaging for assessing brain function changes in depression psychotherapy
张云妍 1夏晓迪 1张坛玮 1周盈 1文可奕 1王芳易 1傅一笑1
作者信息
- 1. 重庆医科大学附属第一医院精神科(重庆 400042)
- 折叠
摘要
心理治疗是抑郁症广泛使用的疗法之一,但目前暂无明确的生物标志物作为疗效指标.使用功能磁共振成像(functional magnetic resonance imaging,fMRI)对抑郁症不同心理治疗前后进行影像学标志物评估,可见对应不同脑区激活及功能连接的改变,如认知行为疗法后患者前额叶皮质激活和动态功能连接变异性改变,正念疗法后颞叶部分脑区可见特征性改变.此外探讨特殊人群及结合互联网的心理干预研究发现其经心理治疗后存在脑区激活及功能连接的改变,这对相应心理治疗的疗效评估有指导意义.本文对不同心理治疗后抑郁症患者fMRI特征性脑区或脑网络改变进行综述,以期为抑郁症患者心理治疗结合脑影像学研究的未来方向做出探讨.
Abstract
Psychotherapy is one of the widely used therapies for depression.Yet there are currently no definitive biological markers as indicators of effectiveness.Using functional magnetic resonance imaging(fMRI)to assess the neuroimaging biomarkers before and after different psychological treatments for depression reveals corresponding changes in brain region activation and functional connectivity.For example,after cognitive-behavioral therapy,the prefrontal cortex of patients may be activated and dynamic functional connectivity variability may change,while mindfulness therapy may show alterations in specific temporal lobe regions.Additionally,studies exploring special populations and internet-based psychological intervention have also found changes in brain region activation and functional connectivity,providing guidance for the efficacy evaluation of corresponding psychotherapies.This article reviews the characteristic brain region or network changes in fMRI activity after different psychotherapies in depressed patients,aiming to discuss future directions for research that integrates neuroimaging with psychological treatment for depression.
关键词
抑郁症/功能磁共振成像/心理疗法/认知行为疗法/正念/功能连接Key words
Depression/Functional magnetic resonance imaging/Psychotherapy/Cognitive behavioral therapy/Mindfulness/Functional connectivity引用本文复制引用
基金项目
重庆市自然科学基金(CSTB2022NSCQ-MSX0121)
出版年
2024
NETL
NSTL
万方数据