红细胞分布宽度、系统免疫炎症指数与重性抑郁障碍的相关性研究
Study of the correlation between red blood cell distribution width,systemic immune-inflammation index with major depressive disorder
金曼 1梁浩 2张石盼 1张雪茹 1井朋 3杨越 3王春阳 3吕佩源1
作者信息
- 1. 河北医科大学(石家庄 050051);河北省人民医院神经内科 河北省脑网络与认知功能重点实验室
- 2. 河北省人民医院心血管内科
- 3. 河北省人民医院神经内科 河北省脑网络与认知功能重点实验室
- 折叠
摘要
目的 探讨外周血红细胞分布宽度(red blood cell distribution width,RDW)、系统免疫炎症指数(sys-temic immune-inflammation index,SII)与重性抑郁障碍(major depressive disorder,MDD)的相关性.方法 回顾性分析2020-2022年于我院临床心理科住院的176例MDD患者和常规体检的209例非MDD对照者的临床资料.从血液分析结果中,得到RDW、SII、红细胞分布宽度与血小板计数比值(RDW to platelet ratio,RPR).绘制受试者操作特征(receiver operator characteristic,ROC)曲线以确定RDW区分患者与对照的最佳临界值及曲线下面积(area un-der the curve,AUC).结果 MDD组患者的RDW[中位数及四分位数:13.20(12.70,13.98)vs.12.80(12.40,13.35)]、SII水平[中位数及四分位数:510.87(350.95,878.12)vs.405.33(313.74,539.92)]高于非MDD组对照者,差异有统计学意义(P<0.05),两组间RPR差异无统计学意义(P>0.05).多因素logistic回归分析结果显示,调整混杂因素后,RDW与MDD呈正关联(OR=3.086,95%CI:1.926～4.944).ROC曲线结果显示,RDW区分MDD与非MDD的最佳临界值为12.85,AUC为0.647(95%CI:0.592～0.702;P<0.001).结论 高RDW可能是MDD发生的危险因素,是对MDD诊断有价值的重要参数.
Abstract
Objective To investigate the correlation between red blood cell distribution width(RDW),systemic immune-inflammation index(SII)and major depressive disorder(MDD).Methods The clinical data of 176 MDD patients hospitalized in the clinical psychology department of our hospital from 2020 to 2022 and 209 non-MDD comparators who were routinely examined in Hebei General Hospital were retrospectively analyzed.Blood analysis was conducted to obtain values of RDW,SII,and red blood cell distribution width/platelet ratio(RPR).The data was used to plot the receiver operator characteristic(ROC)curve to determine the optimal threshold and the area under the curve(AUC)for RDW to discriminate between patients and controls.Result Patients in the MDD group had significantly higher RDW[median and quartiles:13.20(12.70,13.98)vs.12.80(12.40,13.35)],and SII levels[median and quartiles 510.87(350.95,878.12)vs.405.33(313.74,539.92)]compared with those in non-MDD group(P<0.05).There was no significant difference in RPR between the two groups(P>0.05).Multifactorial logistic regression analysis showed that RDW was positively correlated with MDD after adjusting for confounders(OR=3.086,95% CI:1.926-4.944).ROC curve showed that the optimal threshold for RDW to differentiate the risk of developing MDD was 12.85,with an AUC of 0.647(95% CI:0.592-0.702;P<0.001).Conclusion Present study shows that high RDW is a risk factor for the occurrence of MDD and an important parameter for the risk of developing depression.
关键词
红细胞分布宽度/重性抑郁障碍/系统免疫炎症指数/红细胞分布宽度与血小板计数比值/炎症反应/相关性研究/危险因素Key words
Red blood cell distribution width/Major depressive disorder/Systemic immune-inflammation index/Red blood cell distribution width to platelet ratio/Inflammatory response/Correlation studies/Risk factors引用本文复制引用
基金项目
河北省自然科学基金(H2022307075)
河北省医学科学研究课题(20241259)
河北省高端人才资助项目(6833452)
河北省高端人才资助项目(83587216)
出版年
2024
NETL
NSTL
万方数据