帕金森病心血管系统自主神经功能与排尿症状相关性研究
Association between cardiovascular autonomic function and voiding symptoms in Parkinson disease
高子淇 1杨瑞 1黄文琳 2蔡梦飞 2张玉虎1
作者信息
- 1. 华南理工大学医学院(广州 510006);南方医科大学附属广东省人民医院(广东省医学科学院)神经科(广东省神经科学研究所);广州市神经退行性疾病诊治研究重点实验室
- 2. 南方医科大学附属广东省人民医院(广东省医学科学院)神经科(广东省神经科学研究所);广州市神经退行性疾病诊治研究重点实验室
- 折叠
摘要
目的 探讨帕金森病(Parkinson disease,PD)患者心血管系统自主神经功能与排尿症状之间的相关性.方法 回顾性分析2020年11月至2023年7月就诊于广东省人民医院神经内科的PD患者临床资料.根据是否伴有夜间高血压(nocturnal hypertension,NH),将患者分为两组:有夜间高血压的PD患者(PD-NH组)和无夜间高血压的PD患者(PD-nNH组),对排尿指标进行组间比较.根据24 h动态血压监测(ambulatory blood pressure monitoring,ABPM)测量值计算血压平均真实变异性(average real variability,ARV),并使用广义线性模型分析其相关指标.结果 87例PD患者中,46例(52.87%)存在NH.PD-NH组膀胱残余尿量(post void residual,PVR)[1.00(0.00,21.25)mL]多于PD-nNH组[0.00(0.00,5.50)mL],差异有统计学意义(U=1147.000,P<0.05).经广义线性模型分析,PD患者ARV主要受性别(OR=1.234,95%CI:1.050～1.451)和PVR(OR=1.003,95%CI:1.001～1.005)影响.结论 在PD患者自主神经功能障碍中,心血管系统与泌尿系统之间存在相关性.
Abstract
Objective To investigate the association between cardiovascular autonomic function and voiding symptoms in Parkinson disease(PD)patients.Methods We reviewed PD patients from the Department of Neurology of Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)between November 2020 and July 2023.Patients with PD were diagnosed by movement disorder specialists and received motor symptoms assessment based on Movement Disorders Society-Unified Parkinson's Disease Rating Scale part Ⅲ(MDS-UPDRS Ⅲ).We included those patients who underwent 24-hour ambulatory blood pressure monitoring(ABPM),ultrasound measured post void residual(PVR)and uroflowmetry.Subjects were divided into two groups:PD patients with nocturnal hypertension(PD-NH)group and PD patients without nocturnal hypertension(PD-nNH)group,according to the average nocturnal blood pressure.General clinical features,clinical assessments and urinary evaluations were compared between the two groups.We calculated average real variability(ARV)and examined its correlation factors using generalized linear models.Results Among the total of 87 PD patients,46(52.87% )were found to have nocturnal hypertension(NH).The PD-NH group exhibited more PVR[1.00(0.00,21.25)mL]compared to the PD-nNH group[0.00(0.00,5.50)mL](P<0.05).Additionally,generalized linear model analysis which scale response is Gamma with log link showed in PD patients,ARV of 24-hour diastolic blood pressure was correlated with PVR(OR=1.003,95% CI:1.001-1.005,P=0.008)and sex(male,OR=1.234,95% CI:1.050-1.451,P=0.011).Conclusion Our study demonstrates the association between cardiovascular autonomic function and voiding symptoms in PD.
关键词
帕金森病/心血管系统自主神经功能障碍/下尿路症状/夜间高血压/血压变异性/膀胱残余尿量Key words
Parkinson disease/Cardiovascular autonomic dysfunction/Lower urinary tract symptom/Nocturnal hypertension/Blood pressure variability/Post void residual引用本文复制引用
基金项目
国家自然科学基金项目(82071419)
国家自然科学基金项目(82301663)
广州市科技重点研发计划项目(202206010086)
中国博士后科学基金(2023M730742)
出版年
2024
NETL
NSTL
万方数据