注意缺陷多动障碍与炎症关系的研究进展
Research progress on the relationship between attention deficit and hyperactive disorder and inflammation
张永昶 1刘彩燕 1符祥浈 1师玲玲2
作者信息
- 1. 暨南大学附属第一医院精神医学科(广州 510630)
- 2. 暨南大学附属第一医院精神医学科(广州 510630);暨南大学粤港澳中枢神经再生研究院,中枢神经再生教育部重点实验室
- 折叠
摘要
注意缺陷多动障碍(attention deficit and hyperactive disorder,ADHD)发病机制目前尚不明确.流行病学、生物标志物以及遗传相关性三方面的证据提示,炎症可能在ADHD发病机制中发挥重要作用.炎症可以通过激活下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴、改变神经递质代谢、激活母体免疫、影响血脑屏障的完整性、影响神经发育等途径参与ADHD的发生发展.深入了解炎症与ADHD之间的关系,有助于进一步揭示ADHD的病理生理机制,并为其临床诊疗提供新的视角.
Abstract
The pathogenesis of attention deficit and hyperactive disorder(ADHD)remains unclear.Evidence from epidemiological,biomarker,and genetic studies indicates that inflammation may play a crucial role in ADHD development.Inflammation can influence the onset and progression of ADHD through various mechanisms,such as activation of the hypothalamic-pituitary-adrenal(HPA)axis,alterations in neurotransmitter metabolism,maternal immune activation,disruption of the blood-brain barrier integrity,and impacts on neurodevelopment.A deeper understanding of the relationship between inflammation and ADHD could provide valuable insights into the pathophysiological mechanisms of ADHD and open new perspectives for clinical diagnosis and treatment.
关键词
注意缺陷多动障碍/炎症/细胞因子/神经递质/免疫/血脑屏障/生物标志物Key words
Attention deficit and hyperactive disorder/Inflammation/Cytokine/Neurotransmitters/Immunity/Blood-brain barrier/Biomarker引用本文复制引用
基金项目
国家自然科学基金面上项目(82471562)
广东省自然科学基金-面上项目(2024A1515010690)
广州市重点领域研发计划脑科学与类脑研究重大科技专项(202007030011)
高等学校学科创新引智基地中枢神经损伤与修复创新引智基地(B14036)
广东省基层科普行动计划(GDKP2023-3-032)
出版年
2024
NETL
NSTL
万方数据