摘要
目的 分析老年抑郁症住院的患者合并静脉血栓栓塞(venous thromboembolism,VTE)临床特征及相关危险因素.方法 回顾性分析2023年1月至2023年9月在北京安定医院老年病房住院抑郁症患者(年龄≥60岁),其中合并VTE者65例(VTE组),无VTE发生的患者78例(对照组).收集两组患者一般人口学情况、疾病特点、VTE既往史、个人史,以及甲状腺功能、激素水平、血脂水平、D-二聚体等相关实验室指标进行比较,并采用二分类logistic回归分析老年抑郁症住院患者合并VTE的相关危险因素.结果 与对照组相比,VTE组患者年龄较大[(70.94±5.88)岁vs.(68.04±4.92)岁],24项汉密尔顿抑郁量表(Hamilton depression scale,HAMD)总分较高[(26.35±9.28)分vs.(23.19±5.94)分],有VTE既往史的比例较大[13例(20.0%)vs.6例(7.7%)],卧床>72 h比例较高[42例(64.6%)vs.31例(39.7%)],HDL-C水平偏低[(1.27±0.27)mmol/L vs.(1.39±0.28)mmol/L],D-二聚体水平较高[1.91(0.82,3.51)mg/L FEU vs.0.48(0.25,0.80)mg/L FEU],差异均有统计学意义(P<0.05).Logistic回归分析结果显示HAMD总分(OR=1.077,P=0.018)、VTE既往史(OR=4.339,P=0.023)、卧床>72 h(OR=2.449,P=0.044)及D-二聚体水平(OR=2.404,P<0.001)是老年抑郁症住院患者合并VTE的危险因素.结论 老年抑郁症住院合并VTE患者具有年龄偏大、抑郁症状较重、HDL-C水平偏低、D-二聚体水平较高、有VTE既往史及卧床>72 h等临床特点.抑郁症状、VTE既往史、卧床>72h及D-二聚体水平可能是老年抑郁症住院患者合并VTE危险因素.
Abstract
Objective To analyze the clinical characteristics and related to risk factors of late-life depression patients with venous thromboembolism in the elderly ward.Methods A retrospective analysis was conducted on 143 hospitalized depression patients(aged≥60 years)including 65 depression patients with VTE(VTE group)and 78 depression patients without VTE(control group)in the elderly ward of Beijing Anding Hospital from January 2023 to September 2023.The clinic and laboratory data was collected such as general demographic information,relevant clinical data,VTE history,personal history,thyroid function,hormone levels,blood lipid levels and D-dimer to analyze and compare the clinical characteristics of two group patients,and Logistic regression was used to analyze the related risk factors of VTE in patients with depression.Results Compared with control group,patients in the VTE group were older[(70.94±5.88)years vs.(68.04±4.92)years,P<0.05],had a higher total HAMD score(26.35±9.28 vs.23.19±5.94,P<0.05),a higher proportion of a history of VTE[13 cases(20.0%)vs.6 cases(7.7%),P<0.05],a higher proportion of bedridden for more than 72 hours[42 cases(64.6%)vs.31 cases(39.7%),P<0.05],lower HDL-C levels[(1.27±0.27)mmol/L vs.(1.39±0.28)mmol/L,P<0.05],and higher levels of D-dimer[1.91(0.82,3.51)mg/L FEU vs.0.48(0.25,0.80)mg/L FEU,P<0.05].Logistic regression analysis showed that total HAMD scores(OR=1.077,P=0.018),history of VTE(OR=4.339,P=0.023),bedridden for more than 72 hours(OR=2.449,P=0.044),and D-dimer level(OR=2.404,P<0.001)were risk factors for hospitalized late-life depression patients with VTE in the elderly ward.Conclusions Depression patients with VTE in the elderly ward have several clinical characteristics including older age,more severe depressive symptoms,lower HDL-C levels,higher D-dimer levels,and higher proportion of a history of VTE and bedridden for more than 72 hours.Depressive symptoms,a history of VTE,bedridden for more than 72 hours,and D-dimer levels may be risk factors for late-life depression patients with VTE in the elderly ward.
维普
万方数据