Expert consensus on the clinical application of niacin skin flush detection in psychiatry-Expert consensus of CSNP psychiatric disorders research alliance (2024 edition)
Expert consensus on the clinical application of niacin skin flush detection in psychiatry-Expert consensus of CSNP psychiatric disorders research alliance (2024 edition)
中国神经科学学会精神病学基础与临床分会(CSNP)精神病性障碍研究联盟全体成员
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摘要
烟酸皮肤反应钝化是精神病性障碍的一个已知生物内表型特征.通过检测烟酸诱发的皮肤潮红反应程度,可以识别出约30％的精神病性障碍患者具有这一特征,该特征可能与磷脂-炎性失衡的致病机制相关.这一检测为临床医生提供了新的防治思路.为进一步推广该技术的临床应用和操作规范,中国神经科学学会精神病学基础与临床分会(Chinese Society of Neuroscience&Psychiatry,CSNP)精神病性障碍研究联盟讨论并形成了《烟酸皮肤反应检测精神科临床应用专家共识》.本共识探讨烟酸皮肤反应生理机制及其与精神病性障碍相关的异常机制、检测方法、界定标准、作为精神病性障碍生物标志的证据、辅助诊断价值以及临床干预措施,并就该检测的必要性、适用范围、过程标准化、结果解读、靶向干预、在早筛和预防中的价值等问题形成专家建议.
Abstract
Attenuated niacin skin response is a known biological endophenotype of psychotic disorders. By measuring the degree of erythema induced by niacin,about 30％ of psychiatric disorders can be identified as having this characteristic,which may be related to the pathophysiological mechanisms of phospholipid-inflammatory imbalance. This detection provides new prevention and treatment strategies for clinicians. To further promote the clinical application and operational standards of this technique,the Chinese Society of Neuroscience & Psychiatry (CSNP) Psychotic Disorders Research Alliance discussed and formulated the "Expert Consensus on the Clinical Application of Niacin Skin Response Detection in Psychiatry". This consensus delved into the physiological mechanisms of niacin skin reactions,their abnormal mechanisms associated with psychotic disorders,detection methods,defining criteria,evidence as biomarkers for psychotic disorders,auxiliary diagnostic value,and clinical intervention measures. Expert recommendations were formulated regarding the necessity of this detection,its scope of application,standardization of procedures,interpretation of results,targeted interventions,and its value in early screening and prevention.
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