Functional connectivity changes in resting state default networks and its correlation with cognitive impairment in patients with myasthenia gravis based on independent component analysis
Functional connectivity changes in resting state default networks and its correlation with cognitive impairment in patients with myasthenia gravis based on independent component analysis
Objective To study the changes in brain default mode network(DMN)functional connectivity in patients with myasthenia gravis(MG),as well as the relationship between DMN and cognitive function.Methods Prospective inclusion of 39 MG patients who visited the Department of Neurology in the First Affiliated Hospital of Soochow University between January 2020 and December 2022.In addition,40 healthy volunteers matched with MG patients in terms of gender,age,education level,and race during the same period were selected as the healthy control group.We conducted neuropsychological tests,emotional assessments,and resting state magnetic resonance imaging functional scans on all participants.Independent component analysis techniques were used to evaluate the functional connectivity changes of the DMN in the subject's brain.Spearman correlation analysis was used to examine the correlation between the functional connectivity values of DMN in different brain regions and cognitive function in MG patients.Results The overall cognitive function(MMSE and MoCA scores),speech learning and memory abilities(Rey auditory verbal learning test,verbal fluency test),and visual spatial function(clock drawing test)scores of the MG group were significantly reduced compared to the control group(all P＜0.01).In terms of execution ability testing,the completion time of the MG group's connectivity function test was longer than that of the control group(P＜0.01).The Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)score in the MG group were significantly higher than the control group(both P＜0.01).Independent component analysis showed that the default functional connectivity within the left posterior cingulate gyrus in MG patients was weaker compared to the control group(P＜0.05,after FDR correction).The default left posterior cingulate gyrus functional connectivity value in MG patients was positively correlated with MMSE score and symbol digit modalities test score(P＜0.05),but negatively correlated with trail-making test-A and-B time(both P＜0.05).Conclusions MG patients experience a decline in overall cognitive function,speech learning and memory,visual spatial function,and executive function.Functional connectivity within the DMN of the left posterior cingulate gyrus is weakened.There is a correlation between functional connectivity values in different brain regions within the DMN and cognitive scores,suggesting that cognitive impairment in MG patients may be related to central nervous system involvement.
维普
万方数据