Objective To explore the effect of subthalamic nucleus(STN)deep brain stimulation(DBS)on anxiety and depression in patients with Meige syndrome.Methods A total of 25 patients with Meige syndrome who were treated with STN-DBS in General Aviation Hospital from April 2016 to January 2022 were retrospectively included.The scores of Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)and Burke-Fahn-Marsden dystonia rating scale(BFMDRS)before and ≥1 year after operation were compared.Spearman rank correlation was used to analyze the correlation between the degree of improvement of anxiety and depression and the degree of improvement of BFMDRS,dyskinesia and dysfunction.Results The HAMA score,HAMD score and BFMDRS score of patients with Meige syndrome treated with STN-DBS for more than one year were all lower than those before treatment(all P＜0.01),the median(quartile)improvement rates of HAMA,HAMD and BFMDRS were 63％(25％,77％),67％(30％,80％)and 79％(55％,86％).The improvement rate of HAMA score was positively correlated with the improvement rate of BFMDRS score and dyskinesia score(r=0.511,P=0.009;r=0.407,P=0.043),but not correlated with the improvement rate of dysfunction score(P＞0.05).There was no correlation between the improvement rate of HAMD score and the improvement rate of BFMDRS score,dyskinesia score and dysfunction score(all P＞0.05).Conclusions STN-DBS can significantly improve the levels of anxiety and depression in patients with Meige syndrome,and the improvement in anxiety is related to the improvement in motor symptoms.
deep brain stimulationsubthalamic nucleusMeige syndromeanxietydepression
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维普
