Relationship between glycosylated hemoglobin A1C levels and cognitive impairment in Parkinson's disease
Objective To explore the correlation between glycosylated hemoglobin A1C(HbA1c)levels and cognitive impairment in Parkinson's disease(PD)patients,and the related factors of cognitive impairment in PD patients.Methods A total of 81 patients with idiopathic PD admitted to Henan Provincial People's Hospital from September 2020 to May 2023 were enrolled.They were divided into diabetes mellitus group(HbA1c ≥6.5％or previously diagnosed as diabetes,n=38)and control group(HbA1c＜6.5％,n=43).The third part of the Unified Parkinson's Disease Rating Scale(UPDRS Ⅲ)was used to assess motor symptoms.The Hoehn-Yahr(H-Y)scale was used to assess the severity of PD.Cognitive function was evaluated by the Montreal cognitive assessment(MoCA).Spearman correlation analysis was used to explore the correlation between MoCA scores and clinical data in PD patients.Univariate and multivariate logistic regression analysis were used to explore the factors that influence cognitive impairment in PD patients.Results There were significant differences in terms of age,age of onset,incidence of hypertension and coronary heart disease,UPDRS Ⅲ scores and MoCA scores between diabetes mellitus group and control group(all P＜0.05).Spearman correlation analysis showed that MoCA scores were positively correlated with years of education(rs=0.345,P=0.002),and negatively correlated with age,age of onset and HbA1c levels in PD patients(rs=-0.330,P=0.003;rs=-0.332,P=0.002;rs=-0.399,P=0.000).There were significant differences in terms of HbA1c levels between cognitive impairment group and normal cognitive function group(Z=-2.828,P=0.005).Multivariate logistic regression analysis showed that HbA1c was an independent risk factor of cognitive impairment in PD patients(OR=2.361,95％CI:1.248-4.465,P=0.008).Conclusions The higher HbA1c levels are correlated with severe cognitive impairment in PD.HbA1c is an independent risk factor of cognitive impairment in PD patients.
万方数据
维普
