Effects of soybean agglutinin on oxidative stress and inflammatory factors in rabbit small intestines
This study was conducted to explore the effects of soybean agglutinin on oxidative stress and inflammatory factors in rabbit small intestine.Thirty healthy 35-day-old weaned New Zealand white rabbits with a body weight of(725.45±20.10)g were randomly divided into three groups,10 rabbits in each group,and soybean agglutinin was gavaged at doses of 0,17.5,87.5 mg/kg,respectively,for 10 days.After the experiment,duodenal,jejunal and ileal tissues were collected.The results showed that compared with the 0 mg/kg soybean agglutinin group,the total antioxidant capacity(T-AOC)of duodenum,jejunum and ileum of rabbits in the 87.5 mg/kg soybean agglutinin group was significantly decreased by 31.96％,49.27％and 36.35％respectively,the content of malondialdehyde(MDA)was significantly increased by 217.84％,132.46％,and 74.29％respectively(P＜0.05),the activity of superoxide dismutase(SOD)in duodenum and jejunum was significantly decreased by 22.05％and 45.51％(P＜0.05),and the activity of glutathione peroxidase(GSH-Px)in jejunum and ileum was significantly decreased by 36.73％and 29.69％(P＜0.05).Compared with the 0 mg/kg soybean agglutinin group,the content of interleukin-6(IL-6)in the jejunum of rabbits in the 87.5 mg/kg soybean agglutinin group was increased significantly by 21.12％(P＜0.05),and the content of tumor necrosis factor-α(TNF-α)in the ileum of rabbits in the 17.5 mg/kg and 87.5 mg/kg soybean agglutinin group was increased significantly by 55.23％and 65.73％(P＜0.05).The research indicated that in the process of rabbit breeding,the intake of excessive soybean agglutinin could induce the oxidative stress of small intestine tissue,aggravate the inflammatory reaction of the intestine,and damage the intestinal health of rabbits.
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NSTL
万方数据
维普
