In order to explore the effect of oregano oil on the growth performance,immune performance and economic effectiveness of fattening pigs.In this experiment,200(Duroc×Landrace×Large White)ternary crossbred fattening pigs with good health status and weight of about 50kg were randomly divided into 4 groups,and and each group was set with 5 replicates,with 10 pigs in each replicate.The fattening pigs in the control group were fed basal diet,and the three treatment groups were fed with 100,200 mg/kg,and 300 mg/kg oregano oil respectively,and the test was 45 days in total,including 3 days of pre-test and 42 days of trial period.The results showed that:1)Feed addition of 100,200,300 mg/kg oregano oil could significantly increase the ADG of fattening pigs(P<0.05),significantly reduce F/G(P<0.05),and the addition of 200 mg/kg and 300 mg/kg oregano oil could significantly increase the ADFI of fattening pigs(P<0.05).2)Feed addition of 200 mg/kg and 300 mg/kg oregano oil could significantly increase the contents of IgA and IgG in the serum of fattening pigs(P<0.05),and significantly reduce the contents of TNF-α,IL-6 and IL-10(P<0.05).3)Feed addition of 100,200,300 mg/kg oregano oil can significantly reduce the weight gain cost of fattening pigs(P<0.05)and the cost to gain ratio was significantly increase of fattening pigs(P<0.05).And when the addition amount was 200 mg/kg,the effect was the most obvious.