The purpose of this study was to investigate the effects of replacing whole-plant corn silage with millet yellow silage on growth performance,serum biochemical indicators,antioxidant indicators and economic benefits of Simmental crossbred cattle.Thirty-six Simmental crossbred bulls were randomly divided into 4 groups with 9 bulls per group,the control group was fed with total mixed diet,and and the experimental groups were fed with 10%,30%and 50%millet yellow silage instead of whole corn silage.The experiment lasted for 75 days.The results showed as follows:(1)There were no significant differences in initial body weight,final body weight,average daily gain and feed/gain among all groups(P>0.05).(2)The serum urea nitrogen content of western hybrid cattle in experimental groups was significantly lower than that in control group(P<0.05);The activity of glutathione peroxidase in the 10%and 50%millet yellow silage substitution groups was significantly increased by 10.93%and 11.68%compared with the control group(P<0.05);The content of serum malondialdehyde in the 50%replacement group was 11.18%lower than that in the control group(P<0.05).(3)During the 60 day fattening period,the total profit of the 30%substitution group was the highest,72 yuan and 138 yuan higher than the 10%and 50%substitution groups,respectively.In conclusion,replacing whole corn silage with millet yellow silage in diet had no effect on growth performance and serum biochemical indices of Simmental crossbred cattle,replacing 50%could improve antioxidant capacity of Simmental crossbred cattle,and replacing 30%had the highest fending benefit.