This experiment aims to explore the effects of selenium enriched yeast on the growth performance,serum biochemical indicators,and intestinal morphology of piglets.600 healthy piglets with a weight of(8.05±0.23)kg were divided into 4 groups,with 10 replicates in each group,and 15 piglets in each replicate.The experiment lasted for a total of 28 days.Add selenium rich yeast at 0,0.1,0.2,and 0.4 mg/kg as the experimental feed.The results showed that compared with the control group,the FBW of piglets in the selenium enriched yeast group supplemented with 0.2 and 0.4 mg/kg significantly increased by 3.44%and 4.03%(P<0.05);ADG significantly increased by 8.14%and 11.33%(P<0.05);F/G significantly decreased by 7.16%and 9.66%(P<0.05);In addition,selenium enriched yeast had no significant effect on IBW and ADFI(P>0.05).Serum IgA,IgG,and IL-1 in piglets treated with selenium enriched yeast at concentrations of 0.2 and 0.4 mg/kg β The content significantly increased(P<0.05);The serum IgM content of piglets in the selenium enriched yeast group with 0.4 mg/kg was significantly increased(P<0.05);The serum GSH Px activity and T-AOC ability of piglets were significantly increased in the selenium enriched yeast groups of 0.2 and 0.4 mg/kg(P<0.05);The serum H2O2 content of piglets in the selenium enriched yeast groups of 0.2 and 0.4 mg/kg was significantly reduced(P<0.05);In addition,selenium enriched yeast has an effect on the serum TNF-α of piglets.There was no significant effect on NO content and SOD activity(P>0.05).The villus height in the jejunum and ileum of piglets in the 0.2 and 0.4 mg/kg selenium enriched yeast groups was significantly increased(P<0.05);The duodenal crypt depth of piglets in the 0.2 mg/kg selenium enriched yeast group was significantly reduced(P<0.05);The V/C values in the duodenum and ileum of piglets in the 0.2 and 0.4 mg/kg selenium enriched yeast groups were significantly increased(P<0.05);The V/C value of piglets in the 0.2 mg/kg selenium enriched yeast group significantly increased(P<0.05).In summary,based on the comprehensive detection of various indicators in this experiment,the optimal amount of selenium enriched yeast added is 0.2 mg/kg.