The effects of endurance training on growth performance,serum immune indicators,and antioxidant indicators in high fat feed induced obese mice
To investigate the effects of endurance training on the growth performance,serum immune indicators,and antioxidant indicators of high fat feed induced obese mice.Select 120 3-week-old C57 male mice and randomly divide them into 3 groups,with 4 replicates in each group and 10 mice per replicate.The control group mice were fed with regular feed,the obese group mice were fed with high fat feed,and the endurance training group mice were fed with high fat feed and treadmill exercise intervention.The experiment lasted for 4 weeks.The results showed that:(1)Compared with the control group,the final weight of obese mice significantly increased by 36.88% (P＜0.05),and the Lee's index significantly increased by 10.92% (P＜0.05).Compared with the obese group,the Lee's index of mice in the endurance training group was significantly reduced by 5.54% (P＜0.05).(2)Compared with the control group and the obesity group,the endurance training group showed a significant increase in serum IgG levels(P＜0.05)and a significant decrease in serum TNF-α levels(P＜0.05).(3)Compared with the control group,the serum total antioxidant capacity and glutathione peroxidase activity of obese mice were significantly reduced(P＜0.05),and the serum malondialdehyde content was significantly increased(P＜0.05).Compared with the obese group,the endurance training group showed a significant increase in serum total antioxidant capacity(P＜0.05),a highly significant increase in serum glutathione peroxidase activity(P＜0.01),and a significant decrease in serum malondialdehyde content(P＜0.05).In summary,high fat feed can easily induce obesity and oxidative stress in mice,while endurance training can reduce the Lee's index of mice and improve serum immunity and antioxidant capacity.
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