Effects of exercise intervention on obesity and lipid metabolism in mice induced by high-fat feed
To study the effect of exercise intervention on obesity and lipid metabolism in mice induced by high-fat feed.72 1-month-old C57BL/6J male mice were selected,and the mice were randomly divided into three groups,3 repeated in each group,8 repeated.Among them,the CON group feeds ordinary feed,the HFF group feeds high-fat feed,and the HFF+SI group exercises on the basis of feeding high-fat feed.The preliminary trial period is 7 days,and the positive trial period is 30 days.The results showed that(1)during the positive trial period of 20 days and 30 days,the weight of mice in the HFF group increased significantly by 11.15%(P＜0.05)and 22.14%(P＜0.05)compared with the CON group;during the positive trial period of 30 days,the weight of mice in the HFF+SI group decreased significantly by 13.88%(P＜0.05)compared with that in the HFF group.(2)The BMI index and Lee's index of mice in the HFF group were significantly higher than that in the CON group and HFF+SI group(P＜0.05);the body fat rate of mice in the HFF group was significantly higher than that in the CON group(P＜0.05).(3)The serum triglyceride and low-density lipoprotein concentrations of mice in the HFF group were significantly higher than that in the CON group and HFF+SI groups(P＜0.05);the serum total cholesterol concentration of mice in the HFF group was significantly higher than that in the CON group(P＜0.05).It can be seen that high-fat feed causes obesity and lipid metabolism disorders in mice,and exercise intervention reduces obesity and blood lipid levels in mice.
NETL
NSTL
万方数据
