The effect of luteolin on the growth performance,intestinal immune indicators,and intestinal morphology of piglets
The experiment aims to explore the effects of adding luteolin(LUTN)to the feed on the growth performance,intestinal immune indicators,and morphology of piglets.256 healthy and physically fit ternary hybrid pigs(8.31±0.79 kg)were selected for the experiment and randomly divided into 4 groups(8 replicates x 8 pigs per group).The 4 groups were fed with basic feed(control group)and experimental Ⅰ,Ⅱ,and Ⅲ feed supplemented with 15,30,and 60 mg/kg LUTN,respectively.The experiment lasted for 28 days.The results showed that from day 1 to 14,LUTN had a significant effect on the growth performance of piglets(P＞0.05);From 15 to 28 days,the average daily weight gain of piglets in the 60 mg/kg LUTN group increased by 6.69%(P＜0.05),and the feed to meat ratio decreased by 5.50%(P＜0.05).The diarrhea rate of piglets in the 30 and 60 mg/kg LUTN groups decreased by 60.28%and 54.57%,respectively(P＜0.05);From 1 to 28 days,the final weight of piglets in the 60 mg/kg LUTN group increased by 3.72%,the average daily weight gain increased by 5.50%(P＜0.05),and the feed to meat ratio decreased by 4.47%(P＜0.05).The diarrhea rate of piglets in the 30 and 60 mg/kg LUTN groups decreased by 44.31%and 42.02%,respectively(P＜0.05).The SIgA content in each intestinal segment of piglets in the LUTN group at a dose of 60 mg/kg was significantly increased(P＜0.05),while the TNF-α content in the jejunum and ileum was significantly decreased(P＜0.05);The levels of IL-6 in the duodenum and ileum were significantly reduced(P＜0.05);The IL-1 content in the ileum of piglets in the LUTN groups at 30 and 60 mg/kg was significantly increased(P＜0.05).The number of goblet cells in the duodenum of piglets in the LUTN groups at 30 and 60 mg/kg significantly increased(P＜0.05),and the V/C value and lymphocyte count in the jejunum significantly increased(P＜0.05);The number of goblet cells in the ileum significantly increased(P＜0.05).Conclusion:LUTN(60 mg/kg)can significantly improve intestinal immune indicators and morphology,promote piglet growth and development.
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