The inhibiting effects of resistant starch, chitosan oligosaccharide and their complex on high-fat diet induced by oxidative stress and inhibition of fatty liver
This paper investigated the inhibiting effects of resistant starch (RS),chitosan oligosaccharide (CO) and their complex on high-fat diet induced oxidative stress and fatty liver,then adopted RT-PCR to measure related gene expression and preliminarily discussed the mechanism.This complex was made through cross-linked reaction after blending them together.Experimental rats were divided into 5 groups,including normal control group,high fat diet group and 3 different administration groups,administration groups were treated with CO (0.3g/d · per rat),RS (1.2g/d · per rat) and complex (1.5g/d· per rat),normal control and high-fat diet groups' rats treated with same volume distilled water.After 6 weeks,measured rats' body weight,liver mass,oxidative stress and liver function related index.The results showed that,compared with high-fat fed rats without administration,treated with CO and RS complex could significantly decrease high-fat diet rats' body weight,liver mass and liver index,decreased AST,ALT and AKP level,increased T-AOC,T-SOD and GSH Px level,decreased MDA,inhibited Hepatocyte fatty degeneration,the mRNA expression quality of SERBP-I,FATP1 and FABP4 also down-regulated after administration,indicated the preliminary organism of inhabiting the formation of fatty liver.This research also showed better inhibiting effects of complex on High-Fat Diet Induced oxidative stress and fatty liver than those administrated with CO and RS alone.
国家科技期刊平台
NSTL
万方数据
维普
