Hypolipidemic effects of Lactobacillus reuteri CCFM8631 in high-fat diet mice
In this study,the hypolidemic effects of Lactobacillus reuteri CCFM8631 in mice with hyperlipidemia induced by a high-fat diet was investigated. Mice were randomly assigned to three groups:a control group (CK),a hyperlipidemic model group (HFD),and a Lactobacillus reuteri CCFM8631 group (CCFM8631). Following the successful establishment of the hyperlipidemic model,treatment continued for 28 days,body weight,organ indices,and serum levels of various parameters including total cholesterol (TC),triglycerides (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C),liver injury biomarker,inflammatory factors and vascular function were assessed. Results indicated that,compared to the HFD group,mice in the CCFM8631 treatment group showed significant reductions in body weight,liver index,and fat index. Additionally,serum TC,TG,LDL-C levels were significantly decreased,while HDL-C levels significantly elevated in the CCFM8631 group. Moreover,liver injury,inflammatory factors and vascular function were improved in the CCFM8631 treatment group. These findings suggested that Lactobacillus reuteri CCFM8631 had the potential to serve as a lipid-lowering functional dietary supplement for the prevention and treatment of hyperlipidemia.
国家科技期刊平台
NSTL
万方数据
