Embellish aperient bowel effects of Wuren Tea on constipated mice
In order to investigate the embellish aperient bowel effects of Wuren Tea on constipated mice,experimental mice were randomly divided into six groups:a control group (distilled water),a model group (distilled water),a positive control group (5％ Maren Pills) and low,medium-and high-dose treatment groups with WuRen Tea of 1101,5505 and 11010 mg/kg·BW (corresponding to 3,15 and 30 times the recommended dose for humans),respectively. After 14 days of gastric gavage,a constipation model was induced with a suspension of loperamide hydrochloride. The effects of Wuren Tea on the intestinal motility of constipated mice were evaluated by comparing the intestinal ink propulsion rate,time until the first occurrence of black feces,the number of black feces produced within 6 hours,and fecal quality. Results showed that the loperamide hydrochloride suspension effectively induced a constipation model in mice. Comparisons among the model group,positive group,and three dosage groups revealed significant improvements in all evaluation metrics. Notably,the high-dose group of Wuren Tea increased the ink propulsion rate in the small intestine by 27.02％,reduced the time to first black feces by 43.67 minutes,and increased the number of black feces produced within 6 hours (4.67 pieces) and their quality (0.1076 g). The findings indicated that Wuren Tea could enhance intestinal motility in constipated mice,providing a basis for the development of laxative herbal teas.
国家科技期刊平台
NSTL
万方数据
