柠檬酸苹果酸钙颗粒的制备及其在片剂中的应用
Preparation of calcium citrate malate granules and their application in tablet formulation
吕跃峰 1李培杰 1许丽格 1张要华 1赵晨宇1
作者信息
- 1. 郑州瑞普生物工程有限公司,郑州 450001
- 折叠
摘要
采用湿法制粒制备柠檬酸苹果酸钙颗粒,分别对颗粒的理化指标、流散性及外观形态进行了表征,以片重差、硬度、脆碎、崩解等指标考察颗粒的可压性,并探究了其在片剂中的应用.结果显示制粒后柠檬酸苹果酸钙的钙含量、水分、重金属等理化指标均满足国标《GB1903.18-2016食品安全国家标准食品营养强化剂柠檬酸苹果酸钙》规定,粉体流散性得到了显著改善,颗粒大小在60～200目之间,片剂硬度从7.41 kg/cm2提高到±16.6 kg/cm2,以柠檬酸苹果酸钙颗粒制备的片剂具有钙含量高、无灼热感、口感好、硬度适中等优点.本研究制备的柠檬酸苹果酸钙颗粒,可用于开发吸收率高、口感较好的补钙片剂.
Abstract
Calcium citrate malate granules were prepared using a wet granulation method. The physicochemical properties,dispersibility and morphological characteristics of the granules were characterized. The compressibility of the granules was assessed by measuring weight variation,hardness,friability and disintegration time,along with an exploration of their application in tablets. The results showed that the calcium content,moisture,heavy metals,and other physicochemical indicators of the calcium citrate malate granules met the national standard "GB1903.18-2016 National Food Safety Standard for Nutritional Fortifiers Calcium Citrate Malate". The flowability of the powder was significantly improved,with granular size ranging from 60 to 200 mesh. The tablet hardness increased from 7.41 kg/cm2 to approximately 16.6 kg/cm2 after granulation. Tablets made from these calcium citrate malate granules exhibited high calcium content,no burning sensation,a pleasant taste,and moderate hardness. The calcium citrate malate granules prepared in this study can be used for developing calcium supplement tablets with high absorption rates and better palatability.
关键词
柠檬酸苹果酸钙/颗粒/流散性/可压性Key words
calcium citrate malate/granules/flowability/compressibility引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据