Research progress on anti-caking of solid sorbitol
Sorbitol is prone to caking during storage and transportation,hindering its application and handling. This review systematically analyzed factors contributing to the caking of solid sorbitol;various techniques used in investigating these factors were summarized,including high performance liquid chromatography (HPLC),differential scanning calorimetry (DSC),and X-ray diffraction (XRD). The study also discussed the inhibitory effects of anti-caking agents on the clumping of solid sorbitol;substances such as microcrystalline cellulose and silicone oil could reduce clumping to a certain extent. The image analysis technology provided a novel approach for quantitative evaluation of caking severity. Finally,the impact of clumping on the performance of solid sorbitol was addressed,and potential mitigation strategies were proposed. These strategies including utilizing moisture-resistant packaging materials,incorporating desiccants to control humidity,and optimizing particle size to minimize contact area among particles.
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