固体山梨醇抗结块研究进展
Research progress on anti-caking of solid sorbitol
李明阳 1黄强 2李新杰 1李超 2董英炎 1赵风1
作者信息
- 1. 肇庆焕发生物科技有限公司,肇庆 526238
- 2. 华南理工大学,广州 510640
- 折叠
摘要
固体山梨醇容易在储存和运输过程中出现结块现象,严重影响其应用和处理效率.本综述系统分析了固体山梨醇抗结块的影响因素,对探究影响结块因素所用的技术进行了归纳,如高效液相色谱法(HPLC)、差示扫描量热法(DSC)、X射线衍射(XRD)等.此外,阐述了抗结块剂的添加对固体山梨醇结块现象的抑制效果,如微晶纤维素、硅油等,在一定程度上可以减少结块.通过梳理发现,基于图像分析技术的结块评价体系,为定量评估固体山梨醇的结块程度提供了一种新思路.最后,本综述讨论了结块对固体山梨醇性能的影响,以及未来可能的解决策略.比如改善包装材料的阻潮性、采用干燥剂等方法来控制环境湿度,或是通过粒径的优化以减小颗粒间的接触面积.
Abstract
Sorbitol is prone to caking during storage and transportation,hindering its application and handling. This review systematically analyzed factors contributing to the caking of solid sorbitol;various techniques used in investigating these factors were summarized,including high performance liquid chromatography (HPLC),differential scanning calorimetry (DSC),and X-ray diffraction (XRD). The study also discussed the inhibitory effects of anti-caking agents on the clumping of solid sorbitol;substances such as microcrystalline cellulose and silicone oil could reduce clumping to a certain extent. The image analysis technology provided a novel approach for quantitative evaluation of caking severity. Finally,the impact of clumping on the performance of solid sorbitol was addressed,and potential mitigation strategies were proposed. These strategies including utilizing moisture-resistant packaging materials,incorporating desiccants to control humidity,and optimizing particle size to minimize contact area among particles.
关键词
山梨醇/结块/环境湿度/抗结块剂/物理化学性质Key words
sorbitol/caking/ambient humidity/anti-caking agent/physicochemical properties引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据