Study on Preparation, Swelling Characteristics and TPA Properties of N, O-carboxymethyl Chitosan/Alginate Hydrogels
In this paper,the preparation of Ca2+-crosslinked NOCC/sodium alginate (SAL) hydrogel was studied and the effects of NOCC/SAL ratio,CaCl2 concentration,crosslinking pH and the degree of substitution of NOCC on the swelling ratios of the resultant hydrogels in pH 1.2,pH 6.8 and pH 7.4 solutions were investigated.This paper is meaningful for the application of NOCC/SAL hydrogel in intestine-targeted delivery of sensitive compounds.The results indicated that hydrogels yielded by reaction at NOCC/SAL ratio 1∶3,total solid concentration 2％,CaCl2 concentration 1％ and pH 7 had the lowest swelling ratio at pH 1.2 and highest swelling irate at pH 6.8.The degree of substitution of NOCC significantly influenced the swelling and texture properties of the hydrogels.The swelling ratios of the hydrogels in pH 6.8 and pH 7.4 solutions increased along the rise of degree of substitution of NOCC and the swelling ratio in pH 6.8 was higher than that at pH 7.4.The hydrogel prepared with NOCC of 1.1 degree of substitution exhibited the highest hardness.
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