Studies on Carrier Properties of Soybean 7S Protein-Chitosan Self-Assembled Core-Shell Nanoparticles
In this paper,the intermolecular force of soybean 7S and chitosan(CS)was destroyed by urea molecules to fully dissociate them.The dissociated 7S and CS were self-assembled to prepare 7S protein-CS nanoparticles(SCP)driven by hydrophobic and electrostatic attraction.The ζ-potential of the SCP particles was similar to that of the CS,suggesting a"core-shell"structure,which was further confirmed by transmission electron microscopy(TEM).SCP parti-cles were evenly and gradually released during the in vitro digestion process,suggesting that SCP particles possess a specific level of stability in the gastrointestinal environment.In order to examine the characteristics of SCP particles as carriers,the impact of SCP particles on the anticancer properties of curcumin was studied.The results showed that there was no notable disparity in the ability to inhibit the growth of Caco-2 cells between curcumin embedded in SCP particles and free curcumin.This suggests that utilizing SCP particles is an efficient approach to enhance the effectiveness and bi-ological activity of curcumin.
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