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乳源外泌体对微生物的作用

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外泌体是纳米级(直径40~160 nm)的胞外囊泡,在细胞信号转导、免疫应答和抗原递呈过程中发挥作用,并存在于多种体液,包括血清、唾液、尿液、脑脊液和乳液等.乳外泌体携带蛋白质、miRNA等多种功能分子,很多与人体免疫功能相关.摄取乳液后,乳外泌体中的内容物可被人体肠道吸收,从而发挥健康作用.本文总结国内外有关乳源外泌体与微生物关系的研究报道以及本团队的研究成果,阐述外泌体的生物发生过程,主要组成成分,外泌体与病原微生物感染的关系以及乳外泌体对肠道微生物的作用,为研究乳外泌体对人体的营养和健康功效提供参考.
Effects of Milk-derived Exosomes on Microorganisms
Exosomes are nanoscale(40-160 nm in diameter)extracellular vesicles that play a role in cell signal trans-duction,immune response and antigen presentation.They can be isolated from various body fluids,including serum,saliva,urine,cerebrospinal fluid and emulsion,etc.Milk-derived exosomes are endogenous delivery vehicles which con-tain a variety of functional molecules such as proteins and miRNA,many of which are related to human immune func-tion.Milk-derived exosomes can be absorbed by human intestine and exert healthy effects through ingestion of milk.This article summarizes domestic and foreign reports on the relationship between milk-derived exosomes and microorganisms,as well as the research results of our team.In this article,the biogenesis process and main components of exosomes,the relationship between exosomes and pathogenic microbial infection,and the effects of milk-derived exosomes on in-testinal microorganisms were expounded.It provides a reference for studying the nutritional and health effects of milk-de-rived exosomes on human body.

exosomesmicroorganismsgut microbiotabovine milkhuman breast milk

赵紫涵、谭楚敏、吴希阳、谢秋玲

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暨南大学 广州 510632

外泌体 微生物 肠道菌群 牛乳 母乳

2024

中国食品学报
中国食品科学技术学会

中国食品学报

CSTPCD北大核心EI
影响因子:1.079
ISSN:1009-7848
年,卷(期):2024.24(1)
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