Nanozymes with excellent broad-spectrum antibacterial properties provide a novel strategy to solve the problem of food spoilage caused by microorganisms.Nanozymes can catalyze the corresponding substrates to generate reactive oxy-gen species(ROS)in a physiological environment.At the same time,because of their simple preparation,low cost,high catalytic efficiency,easy large-scale production and high stability,they have broad applications in the field of food preservation prospect.Therefore,this review comprehensively summarizes the classification of nanozymes,including metal or metal oxide-based nanozymes,carbon-based nanozymes,polymer-based nanozymes,and other materials,and also e-laborates on the main factors regulating the antibacterial activity of nanozymes(size,morphology,coating and modifica-tion,composition,etc.),which provides effective guidance for how to design efficient antibacterial nanozymes.Most im-portantly,the unique application of nanozymes in food preservation,including the application of nanozyme-based antibac-terial films and its application in the detection of bacterial contamination levels in food,is described in this paper.Due to its broad-spectrum antibacterial properties and negligible biotoxicity,antibacterial nanozymes can reduce the harm of microorganisms in the food industry,and help to control cross-contamination problems in food production and processing.Sustainable development is of great practical significance.All in all,antibacterial nanozymes are expected to become a novel antibacterial agent and/or strategy,and show broad application prospects in food preservation.