Metabolomics Analysis of JFP-Ps in Serum of DSS Colitis Rats
UPLC-Q-TOF-MS/MS was used to analyze the metabolite profiles of JFP-Ps(Polysaccharides from Artocarpus heterophyllus Lam.pulp)in the serum of DSS colitis rats.Then metabonomics analysis was used to explore the serum metabolite profiles and metabolic pathway.The results showed that JFP-Ps mainly regulated these metabolites such as amino acids,peptides and their analogues,purines and pyrimidines and their derivatives,lipids and lipid-like molecules.There are 5 metabolic pathways related to enteritis in rat serum,namely arginine biosynthesis,D-arginine and D-or-nithine metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,phenylalanine metabolism,arginine and proline metabolism.The results indicate that JFP-Ps can attenuate inflammation by regulating amino acid metabolism and influ-encing related pathways in rats with DSS-induced colitis.
polysaccharides from Artocarpus heterophyllus Lam.pulp(JFP-Ps)colitis ratsserumUPLC-Q-TOF-MS/MSmetabolomics
万方数据
维普
