UPLC-Q-TOF-MS/MS was used to analyze the metabolite profiles of JFP-Ps(Polysaccharides from Artocarpus heterophyllus Lam.pulp)in the serum of DSS colitis rats.Then metabonomics analysis was used to explore the serum metabolite profiles and metabolic pathway.The results showed that JFP-Ps mainly regulated these metabolites such as amino acids,peptides and their analogues,purines and pyrimidines and their derivatives,lipids and lipid-like molecules.There are 5 metabolic pathways related to enteritis in rat serum,namely arginine biosynthesis,D-arginine and D-or-nithine metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,phenylalanine metabolism,arginine and proline metabolism.The results indicate that JFP-Ps can attenuate inflammation by regulating amino acid metabolism and influ-encing related pathways in rats with DSS-induced colitis.
关键词
菠萝蜜多糖/肠炎大鼠/血液/超高液相串联四极杆飞行时间质谱/代谢组学
Key words
polysaccharides from Artocarpus heterophyllus Lam.pulp(JFP-Ps)/colitis rats/serum/UPLC-Q-TOF-MS/MS/metabolomics
维普
万方数据