首页|浮游态和生物被膜态致病菌的光动力灭菌研究进展

浮游态和生物被膜态致病菌的光动力灭菌研究进展

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光动力灭菌是一种新兴的致病菌杀灭技术.它通过光源激发光敏剂,产生活性氧自由基,多靶点作用于细菌细胞膜和DNA,造成氧化损伤并最终导致细菌死亡.传统灭菌方式在应用于食品工业时面临诸多问题,如导致耐药性细菌的出现,难以杀灭生物被膜态细菌,造成食品营养和风味流失,应用成本过高等.光动力灭菌作为非热杀菌技术,不会引发食品的感官变化和营养流失,所需设备简单,不易引发细菌耐药性,并且对细菌(浮游态和生物被膜态)、真菌、甚至孢子都有较好的杀灭作用,近年来受到广泛关注.本文概述光动力灭菌的原理和传统杀菌方法的局限性,重点阐述光动力灭菌在杀灭浮游态细菌和生物被膜态细菌中的应用和研究进展.
Research Progress on Photodynamic Inactivation of Planktonic and Biofilm Bacteria
Photodynamic inactivation is a new pathogenic bacterium killing technology.It activates photosensitizers through light sources to generate reactive oxygen species that target bacterial cell membranes and DNA,causing oxidative damage and ultimately leading to bacterial death.Traditional sterilization methods are faced with many problems in the food in-dustry,such as the emergence of drug-resistant bacteria,biofilm bacteria are difficult to kill,food nutrition and flavor loss,and the high cost to application.As a non-thermal sterilization technology,photodynamic inactivation does not cause sensory changes and nutrient loss of food,requires simple equipment and low energy consumption,does not cause bacterial resistance,and has a good killing effect on bacteria(planktonic bacteria and biofilm),fungi,and even spores,which has attracted widespread attention in recent years.This article reviewed the limitations of traditional antibacterial methods,the principle of photodynamic inactivation,and the research progress of photodynamic inactivation in killing planktonic bacteria and biofilm bacteria are emphasized.

photodynamic inactivationbiofilmphotosensitizerfoodborne pathogensfood industry

李栋辉、石玉刚

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浙江工商大学食品与生物工程学院 杭州 310035

浙江工商大学生物技术研究所 杭州 310035

光动力灭菌 生物被膜 光敏剂 食源性致病菌 食品工业

浙江省基础公益研究计划浙江省教育厅科研项目浙江省引智项目一流学科建设国际合作研究项目

LGJ19C200001Y201016439Z201704072017SICR109

2024

中国食品学报
中国食品科学技术学会

中国食品学报

CSTPCD北大核心EI
影响因子:1.079
ISSN:1009-7848
年,卷(期):2024.24(4)
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