中国食品学报2024,Vol.24Issue(5) :479-491.DOI:10.16429/j.1009-7848.2024.05.040

食源性多酚干预酒精性肝病研究进展

Research Progress on the Intervention of Food-borne Polyphenols in Alcoholic Liver Disease

王紫琳 陶亮 杨敏 王远利 王悦 田洋
中国食品学报2024,Vol.24Issue(5) :479-491.DOI:10.16429/j.1009-7848.2024.05.040

食源性多酚干预酒精性肝病研究进展

Research Progress on the Intervention of Food-borne Polyphenols in Alcoholic Liver Disease

王紫琳 1陶亮 2杨敏 1王远利 1王悦 1田洋2
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作者信息

  • 1. 云南农业大学食品科学技术学院 昆明 650000
  • 2. 云南农业大学食品科学技术学院 昆明 650000;食药同源资源开发与利用教育部工程研究中心 昆明 650000;云南省药食同源功能食品工程研究中心 昆明 650000;云南省精准营养与个性化食品制造重点实验室 昆明 650000
  • 折叠

摘要

酒精性肝病是因大量或高频率饮酒而导致的肝脏疾病,初期表现为酒精性脂肪肝,进而发展成酒精性肝炎、肝硬化,甚至肝癌.酗酒会导致肝细胞坏死与肝衰竭.目前寻找有效预防或改善酒精性肝病的活性成分成为研究热点.多酚类化合物广泛存在于蔬菜、水果、谷物等食物中,具有干预酒精性肝病的作用,而其对酒精性肝病的干预作用鲜有系统性的论述.本文综述酒精性肝病的发病机制以及具有干预酒精性肝损伤的食源性多酚的调控机理,以期为研发具有缓解酒精性肝损伤作用的多酚类保健食品提供一定的理论依据.

Abstract

Alcoholic liver disease is a liver disease caused by heavy or high frequency of alcohol consumption,which initially manifests as alcoholic fatty liver,and progresses to alcoholic hepatitis,cirrhosis,and even liver cancer.Alco-holism can lead to liver cell death and liver failure.At present,the search for effective active ingredients to prevent or improve alcoholic liver disease has become a research hotspot.Polyphenols are widely found in vegetables,fruits,cereals et al.,and affect the intervention of alcoholic liver disease.However,the intervention effect on alcoholic liver disease has rarely been systematically discussed.In this review,the pathogenesis of alcoholic liver disease and the regulation mechanism of food-borne polyphenols that could interfere with alcoholic liver injury were summary to provide a theoreti-cal basis for the research and develop polyphenol health food with the effect of alleviating alcoholic liver injury.

关键词

食源性多酚/酒精性肝病/作用机制

Key words

food-borne polyphenols/alcoholic liver disease/mechanism of action

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基金项目

云南省科技重大专项(202102AE090027-2)

云南省科技重大专项(202002AA100005)

云南省万人计划产业技术领军人才项目(YNWR-CYJS-2020-010)

云南省凤庆县核桃产业科技特派团项目(202204BI090012)

出版年

2024
中国食品学报
中国食品科学技术学会

中国食品学报

CSTPCDCSCD北大核心EI
影响因子:1.079
ISSN:1009-7848
被引量1
参考文献量3
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