Impact of Edible Bird's Nest and Sialic Acid on Antioxidant Ability:A Qualitative Evidence-based Study
Background:The consumption of Edible Bird's Nests(EBN)has a long history.It has been regarded as a high-grade health food and tonic due to its characteristics of high nutritional values and medicinal properties.Although some studies stated that EBN or its active ingredients,sialic acid,has antioxidant effects,there is a lack of studies that systematically investigate the antioxidant effects of EBN.Objective:To systematically evaluate the efficacy of EBN on an-tioxidant capacity.Method:Relevant studies published between September 1,2012,and September 1,2022,were searched and selected using'bird nest OR sialic acid'and'antioxidant'as search terms across China National Knowl-edge Infrastructure(CNKI),Wanfang Database,China Biology Medicine disc(CBMdisc),PubMed and Embase.The se-lection of relevant studies was guided by predefined inclusion and exclusion criteria.The bias risks of selected studies were based on the SYRCLE's animal research bias risk tool.Result:Six animal model experiments were finally included in total.Results suggested that EBN and sialic acid has a potential role in up-regulating antioxidant activities.EBN or sialic acid may enhance antioxidant capacity by increasing the levels of antioxidants,while simultaneously reducing the occurrence of inflammation and oxidative stress.However,this review did not conduct a meta-analysis.Conclusion:Ani-mal studies indicate a dose-dependent improvement in antioxidant capacity with EBN and sialic acid,but their effects on humans remain uncertain due to the absence of clinical trials.
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